OBJECTIVE: The current frequency weighting proposed in the International Standards Organization-5349 standard may underestimate the risk of injury associated with exposure to vibration >100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration. METHODS: The effects of exposure to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats. RESULTS: Vascular responses indicative of dysfunction (eg, remodeling and oxidative activity) became more pronounced as the frequency of the exposure increased. CONCLUSION: Exposure to vibration frequencies that induce the greatest stress and strain on the tail (ie, >100 Hz) result in vascular changes indicative of dysfunction.
OBJECTIVE: The current frequency weighting proposed in the International Standards Organization-5349 standard may underestimate the risk of injury associated with exposure to vibration >100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration. METHODS: The effects of exposure to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats. RESULTS: Vascular responses indicative of dysfunction (eg, remodeling and oxidative activity) became more pronounced as the frequency of the exposure increased. CONCLUSION: Exposure to vibration frequencies that induce the greatest stress and strain on the tail (ie, >100 Hz) result in vascular changes indicative of dysfunction.
Authors: Kristine Krajnak; G Roger Miller; Stacey Waugh; Claud Johnson; Michael L Kashon Journal: J Occup Environ Med Date: 2012-08 Impact factor: 2.162
Authors: Stacey Waugh; Michael L Kashon; Shengqiao Li; Gerome R Miller; Claud Johnson; Kristine Krajnak Journal: J Occup Environ Med Date: 2016-04 Impact factor: 2.162
Authors: K Krajnak; S Waugh; C Johnson; R G Miller; D Welcome; X Xu; C Warren; S Sarkisian; M Andrew; R G Dong Journal: J Toxicol Environ Health A Date: 2015
Authors: Kristine Krajnak; Danny A Riley; John Wu; Thomas McDowell; Daniel E Welcome; Xueyan S Xu; Ren G Dong Journal: Ind Health Date: 2012 Impact factor: 2.179