Kristine Krajnak1, Stacey Waugh, Khachatur Sarkisian. 1. Engineering Controls and Technology Branch (Dr Krajnak, Ms Waugh); Biostatistics and Epidemiology Branch (Mr Sarkisian), National Institute for Occupational Safety and Health, Morgantown, West Virginia.
Abstract
OBJECTIVES: Laser Doppler blood flow measurements have been used for diagnosis or detection of peripheral vascular dysfunction. This study used a rat tail model of vibration-induced vascular injury to determine how laser Doppler measurements were affected by acute and repeated exposures to vibration, and to identify changes in the Doppler signal that were associated with the exposure. METHODS: Blood flow was measured immediately after a single exposure to vibration, or before vibration exposure on days 1, 5, 10, 15, and 20 of a 20 days exposure. RESULTS: After a single exposure to vibration, average tail blood flow was reduced. With 20 days of exposure, there was a reduction in the amplitude of the arterial pulse on days 10 to 20 in vibrated rats and days 15 to 20 in control rats. CONCLUSIONS: More detailed statistical analyses of laser Doppler data may be needed to identify early changes in peripheral circulation after exposure to vibration.
OBJECTIVES: Laser Doppler blood flow measurements have been used for diagnosis or detection of peripheral vascular dysfunction. This study used a rat tail model of vibration-induced vascular injury to determine how laser Doppler measurements were affected by acute and repeated exposures to vibration, and to identify changes in the Doppler signal that were associated with the exposure. METHODS: Blood flow was measured immediately after a single exposure to vibration, or before vibration exposure on days 1, 5, 10, 15, and 20 of a 20 days exposure. RESULTS: After a single exposure to vibration, average tail blood flow was reduced. With 20 days of exposure, there was a reduction in the amplitude of the arterial pulse on days 10 to 20 in vibrated rats and days 15 to 20 in control rats. CONCLUSIONS: More detailed statistical analyses of laser Doppler data may be needed to identify early changes in peripheral circulation after exposure to vibration.
Authors: Brian D Curry; Sandya R Govindaraju; James L W Bain; Lin Ling Zhang; Ji-Geng Yan; Hani S Matloub; Danny A Riley Journal: Anat Rec A Discov Mol Cell Evol Biol Date: 2005-06
Authors: Brian D Curry; James L W Bain; Ji-Geng Yan; Lin Ling Zhang; Mark Yamaguchi; Hani S Matloub; Danny A Riley Journal: Muscle Nerve Date: 2002-04 Impact factor: 3.217
Authors: Martin Cherniack; Timothy F Morse; Anthony J Brammer; Ronnie Lundstrom; Jon D Meyer; Tohr Nilsson; Donald Peterson; Esko Toppila; Nick Warren; Rongwei Fu; Heather Bruneau; Marc Croteau Journal: Am J Ind Med Date: 2004-06 Impact factor: 2.214
Authors: Janet A Thompson; Kristine Krajnak; Richard A Johnston; Michael L Kashon; Walter McKinney; Jeffrey S Fedan Journal: Toxicol Rep Date: 2021-12-07