Sirilata Yotphan1, Robert G Bergman, Jonathan A Ellman. 1. Department of Chemistry, University of California and Division of Chemical Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Abstract
An efficient method is reported for the preparation of multicyclic pyridines and quinolines by a rhodium-catalyzed intramolecular C-H bond functionalization process. The method shows good scope for branched and unbranched alkyl substituents on the pyridine ring and at the R position of the tethered alkene group. Starting materials capable of undergoing olefin isomerization to provide terminal 1,1-disubstituted alkenes also proved to be effective substrates.
An efficient method is reported for the preparation of multicyclic pyridines and n class="Chemical">quinolines by a rhodium-catalyzed intramolecular C-H bond functionalization process. The method shows good scope for branched and unbranched alkyl substituents on the pyridine ring and at the R position of the tethered alkene group. Starting materials capable of undergoing olefin isomerization to provide terminal 1,1-disubstituted alkenes also proved to be effective substrates.
Authors: Jason C Rech; Michihisa Yato; Derek Duckett; Brian Ember; Philip V LoGrasso; Robert G Bergman; Jonathan A Ellman Journal: J Am Chem Soc Date: 2007-01-24 Impact factor: 15.419
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