| Literature DB >> 18606543 |
L Nathan Tumey1, Diane H Boschelli, Julie Lee, Divya Chaudhary.
Abstract
A series of 2-alkenyl thieno[2,3-b]pyridine inhibitors of PKCtheta were synthesized as potential inflammatory modulators. This series led to the discovery of 2-alkenyl amides, which are exceptionally potent and selective inhibitors of PKCtheta. Compound 8 has an IC(50) of 3.8nM against PKCtheta and shows excellent selectivity over a variety of PKC isoforms.Entities:
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Year: 2008 PMID： 18606543 DOI： 10.1016/j.bmcl.2008.06.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823