Literature DB >> 20515732

Replication protein A: directing traffic at the intersection of replication and repair.

Greg G Oakley1, Steve M Patrick.   

Abstract

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

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Year:  2010        PMID： 20515732      PMCID： PMC3399740          DOI： 10.2741/3652

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN： 2768-6698


  191 in total

Review 1.  Base excision repair of DNA in mammalian cells.

Authors:  H E Krokan; H Nilsen; F Skorpen; M Otterlei; G Slupphaug
Journal:  FEBS Lett       Date:  2000-06-30       Impact factor: 4.124

2.  Est1 and Cdc13 as comediators of telomerase access.

Authors:  S K Evans; V Lundblad
Journal:  Science       Date:  1999-10-01       Impact factor: 47.728

3.  Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA.

Authors:  Elena Bochkareva; Sergey Korolev; Susan P Lees-Miller; Alexey Bochkarev
Journal:  EMBO J       Date:  2002-04-02       Impact factor: 11.598

4.  Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage.

Authors:  Y Wang; X Y Zhou; H Wang; M S Huq; G Iliakis
Journal:  J Biol Chem       Date:  1999-07-30       Impact factor: 5.157

5.  Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication.

Authors:  S J Brill; B Stillman
Journal:  Nature       Date:  1989-11-02       Impact factor: 49.962

6.  Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation.

Authors:  Hui-I Kao; Judith L Campbell; Robert A Bambara
Journal:  J Biol Chem       Date:  2004-09-22       Impact factor: 5.157

7.  The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA.

Authors:  Timur Yusufzai; Xiangduo Kong; Kyoko Yokomori; James T Kadonaga
Journal:  Genes Dev       Date:  2009-09-30       Impact factor: 11.361

8.  Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.

Authors:  Z Q Pan; A A Amin; E Gibbs; H Niu; J Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

9.  The transactivator proteins VP16 and GAL4 bind replication factor A.

Authors:  Z He; B T Brinton; J Greenblatt; J A Hassell; C J Ingles
Journal:  Cell       Date:  1993-06-18       Impact factor: 41.582

10.  RPA regulates telomerase action by providing Est1p access to chromosome ends.

Authors:  Vera Schramke; Pierre Luciano; Vanessa Brevet; Sylvine Guillot; Yves Corda; Maria Pia Longhese; Eric Gilson; Vincent Géli
Journal:  Nat Genet       Date:  2003-12-21       Impact factor: 38.330
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  104 in total

1.  Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.

Authors:  Sarah R Hengel; Eva Malacaria; Laura Folly da Silva Constantino; Fletcher E Bain; Andrea Diaz; Brandon G Koch; Liping Yu; Meng Wu; Pietro Pichierri; M Ashley Spies; Maria Spies
Journal:  Elife       Date:  2016-07-19       Impact factor: 8.140

2.  Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors.

Authors:  Navnath S Gavande; Pamela S VanderVere-Carozza; Katherine S Pawelczak; Tyler L Vernon; Matthew R Jordan; John J Turchi
Journal:  ACS Med Chem Lett       Date:  2020-01-02       Impact factor: 4.345

3.  The nuclear DEK interactome supports multi-functionality.

Authors:  Eric A Smith; Eric F Krumpelbeck; Anil G Jegga; Malte Prell; Marie M Matrka; Ferdinand Kappes; Kenneth D Greis; Abdullah M Ali; Amom R Meetei; Susanne I Wells
Journal:  Proteins       Date:  2017-11-11

4.  Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes.

Authors:  Sandra Martins; Christopher E Pearson; Paula Coutinho; Sylvie Provost; António Amorim; Marie-Pierre Dubé; Jorge Sequeiros; Guy A Rouleau
Journal:  Hum Genet       Date:  2014-07-16       Impact factor: 4.132

5.  Structure of the SSB-DNA polymerase III interface and its role in DNA replication.

Authors:  Aimee H Marceau; Soon Bahng; Shawn C Massoni; Nicholas P George; Steven J Sandler; Kenneth J Marians; James L Keck
Journal:  EMBO J       Date:  2011-08-19       Impact factor: 11.598

6.  RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Authors:  Huzefa Dungrawala; Kamakoti P Bhat; Rémy Le Meur; Walter J Chazin; Xia Ding; Shyam K Sharan; Sarah R Wessel; Aditya A Sathe; Runxiang Zhao; David Cortez
Journal:  Mol Cell       Date:  2017-07-20       Impact factor: 17.970

7.  NONO regulates the intra-S-phase checkpoint in response to UV radiation.

Authors:  L Alfano; C Costa; A Caporaso; A Altieri; P Indovina; M Macaluso; A Giordano; F Pentimalli
Journal:  Oncogene       Date:  2015-04-20       Impact factor: 9.867

Review 8.  RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response.

Authors:  Alexandre Maréchal; Lee Zou
Journal:  Cell Res       Date:  2014-11-18       Impact factor: 25.617

9.  DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

Authors:  Amanda K Ashley; Meena Shrivastav; Jingyi Nie; Courtney Amerin; Kyle Troksa; Jason G Glanzer; Shengqin Liu; Stephen O Opiyo; Diana D Dimitrova; Phuong Le; Brock Sishc; Susan M Bailey; Greg G Oakley; Jac A Nickoloff
Journal:  DNA Repair (Amst)       Date:  2014-05-10

10.  Interplay of DNA damage and cell cycle signaling at the level of human replication protein A.

Authors:  Gloria E O Borgstahl; Kerry Brader; Adam Mosel; Shengqin Liu; Elisabeth Kremmer; Kaitlin A Goettsch; Carol Kolar; Heinz-Peter Nasheuer; Greg G Oakley
Journal:  DNA Repair (Amst)       Date:  2014-06-13
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