Literature DB >> 20498399

Decision making by parents of children with incurable cancer who opt for enrollment on a phase I trial compared with choosing a do not resuscitate/terminal care option.

Scott H Maurer1, Pamela S Hinds, Sheri L Spunt, Wayne L Furman, Javier R Kane, Justin N Baker.   

Abstract

PURPOSE: Parents of children with incurable cancer make complex and difficult decisions about remaining treatment options. We compared the self-reported rationale, good parent definition, and desired clinical staff behaviors of parents who recently decided for phase I (P1) chemotherapy with parents who chose a do not resuscitate (DNR) or terminal care (TC) option. PATIENTS AND METHODS: Sixty-two parents of 58 children were asked for the basis of their decision, their definition of a good parent, and what staff behaviors supported their good parent role. After semantic content analysis, results were compared in the P1 versus DNR/TC groups. These categories were mutually exclusive but did not necessarily represent an either/or decision.
RESULTS: Thirty-one decisions were for P1 chemotherapy and 27 for DNR/TC. Median survival time after study enrollment was greater in the P1 group (0.4 v 0.1 years). Most P1 group parents reported having felt compelled to continue cancer-directed therapy (71% v 7%), whereas those who opted for DNR/TC cited quality of life (QOL; 74% v 3%) and patient wishes (67% v 13%). Decision factors common to both groups were medical facts, doing right, and others' opinions. Both groups believed that a good parent did right, provided support and presence, and sacrificed for the child. The groups desired similar support from clinicians and expressed gratitude.
CONCLUSION: Despite similar definitions of a good parent and desired staff behaviors, parents in the P1 group reported having felt compelled to continue cancer-directed therapy, whereas QOL and patient wishes were emphasized in decisions for DNR/TC.

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Year:  2010        PMID: 20498399      PMCID: PMC2903327          DOI: 10.1200/JCO.2009.26.6502

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN: 0732-183X            Impact factor:   44.544


  16 in total

1.  The Seattle Pediatric Palliative Care Project: effects on family satisfaction and health-related quality of life.

Authors:  Ross M Hays; Jeanette Valentine; Gerri Haynes; J Russel Geyer; Nanci Villareale; Beth McKinstry; James W Varni; Shervin S Churchill
Journal:  J Palliat Med       Date:  2006-06       Impact factor: 2.947

2.  Decision making by parents and healthcare professionals when considering continued care for pediatric patients with cancer.

Authors:  P S Hinds; L Oakes; W Furman; P Foppiano; M S Olson; A Quargnenti; J Gattuso; B Powell; D K Srivastava; D Jayawardene; J T Sandlund; C Strong
Journal:  Oncol Nurs Forum       Date:  1997-10       Impact factor: 2.172

3.  End-of-life decisions and palliative care in a children's hospital.

Authors:  Gim H Tan; Balagangadhar R Totapally; Dan Torbati; Jack Wolfsdorf
Journal:  J Palliat Med       Date:  2006-04       Impact factor: 2.947

4.  End-of-life care preferences of pediatric patients with cancer.

Authors:  Pamela S Hinds; Donna Drew; Linda L Oakes; Maryam Fouladi; Sheri L Spunt; Christopher Church; Wayne L Furman
Journal:  J Clin Oncol       Date:  2005-09-19       Impact factor: 44.544

5.  Parents of children with cancer: factors influencing their treatment decision making roles.

Authors:  Kimberly A Pyke-Grimm; Janet L Stewart; Katherine P Kelly; Lesley F Degner
Journal:  J Pediatr Nurs       Date:  2006-10       Impact factor: 2.145

6.  Parental perspectives on end-of-life care in the pediatric intensive care unit.

Authors:  Elaine C Meyer; Jeffrey P Burns; John L Griffith; Robert D Truog
Journal:  Crit Care Med       Date:  2002-01       Impact factor: 7.598

7.  Understanding of prognosis among parents of children who died of cancer: impact on treatment goals and integration of palliative care.

Authors:  J Wolfe; N Klar; H E Grier; J Duncan; S Salem-Schatz; E J Emanuel; J C Weeks
Journal:  JAMA       Date:  2000-11-15       Impact factor: 56.272

8.  Factors that distinguish symptoms of most concern to parents from other symptoms of dying children.

Authors:  Michele Pritchard; Elizabeth A Burghen; Jami S Gattuso; Nancy K West; Poorna Gajjar; Deo Kumar Srivastava; Sheri L Spunt; Justin N Baker; Javier R Kane; Wayne L Furman; Pamela S Hinds
Journal:  J Pain Symptom Manage       Date:  2010-04       Impact factor: 3.612

9.  Talking about death with children who have severe malignant disease.

Authors:  Ulrika Kreicbergs; Unnur Valdimarsdóttir; Erik Onelöv; Jan-Inge Henter; Gunnar Steineck
Journal:  N Engl J Med       Date:  2004-09-16       Impact factor: 91.245

10.  Understanding parents' approaches to care and treatment of children with cancer when standard therapy has failed.

Authors:  Myra Bluebond-Langner; Jean Bello Belasco; Ann Goldman; Carmen Belasco
Journal:  J Clin Oncol       Date:  2007-06-10       Impact factor: 44.544

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  40 in total

1.  Chemotherapy versus supportive care alone in pediatric palliative care for cancer: comparing the preferences of parents and health care professionals.

Authors:  Deborah Tomlinson; Ute Bartels; Janet Gammon; Pamela S Hinds; Jocelyne Volpe; Eric Bouffet; Dean A Regier; Sylvain Baruchel; Mark Greenberg; Maru Barrera; Hilary Llewellyn-Thomas; Lillian Sung
Journal:  CMAJ       Date:  2011-10-17       Impact factor: 8.262

2.  Practical communication guidance to improve phase 1 informed consent conversations and decision-making in pediatric oncology.

Authors:  Liza-Marie Johnson; Angela C Leek; Dennis Drotar; Robert B Noll; Susan R Rheingold; Eric D Kodish; Justin N Baker
Journal:  Cancer       Date:  2015-04-14       Impact factor: 6.860

3.  Ethics consultation in pediatrics: long-term experience from a pediatric oncology center.

Authors:  Liza-Marie Johnson; Christopher L Church; Monika Metzger; Justin N Baker
Journal:  Am J Bioeth       Date:  2015       Impact factor: 11.229

4.  Parent-clinician communication intervention during end-of-life decision making for children with incurable cancer.

Authors:  Pamela S Hinds; Linda L Oakes; Judy Hicks; Brent Powell; Deo Kumar Srivastava; Justin N Baker; Sheri L Spunt; Nancy K West; Wayne L Furman
Journal:  J Palliat Med       Date:  2012-06-26       Impact factor: 2.947

5.  Physician and nurse beliefs of phase 1 trials in pediatric oncology.

Authors:  Margaux J Barnes; Joseph Pressey; Julia Adams; Molly A Hensler; Avi Madan-Swain
Journal:  Cancer Nurs       Date:  2014 Sep-Oct       Impact factor: 2.592

Review 6.  Challenging issues in pediatric oncology.

Authors:  Ching-Hon Pui; Amar J Gajjar; Javier R Kane; Ibrahim A Qaddoumi; Alberto S Pappo
Journal:  Nat Rev Clin Oncol       Date:  2011-06-28       Impact factor: 66.675

7.  The parent perspective: "being a good parent" when making critical decisions in the PICU.

Authors:  Tessie W October; Kiondra R Fisher; Chris Feudtner; Pamela S Hinds
Journal:  Pediatr Crit Care Med       Date:  2014-05       Impact factor: 3.624

8.  Symptoms and Distress in Children With Advanced Cancer: Prospective Patient-Reported Outcomes From the PediQUEST Study.

Authors:  Joanne Wolfe; Liliana Orellana; Christina Ullrich; E Francis Cook; Tammy I Kang; Abby Rosenberg; Russ Geyer; Chris Feudtner; Veronica Dussel
Journal:  J Clin Oncol       Date:  2015-04-27       Impact factor: 44.544

Review 9.  Bending the Cost Curve in Childhood Cancer.

Authors:  Heidi Russell; M Brooke Bernhardt
Journal:  Curr Hematol Malig Rep       Date:  2016-08       Impact factor: 3.952

Review 10.  Palliative care for children with cancer.

Authors:  Elisha Waldman; Joanne Wolfe
Journal:  Nat Rev Clin Oncol       Date:  2013-01-22       Impact factor: 66.675

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