Literature DB >> 2049567

Light sheds light on cancer--distinguishing malignant tumors from benign tissues and tumors.

R R Alfano1, B B Das, J Cleary, R Prudente, E J Celmer.   

Abstract

Difference in fluorescence spectra from human malignant and benign tumors, benign and normal breast tissues were measured. Spectral histograms from 40 samples show the diagnostic possibilities of this optical technology. Fluorescence from model fluorophores (nucleotides, amino acids, and proteins) were used to speculate on the sources of marked features of the tissue fluorescence.

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Year:  1991        PMID: 2049567      PMCID: PMC1809828     

Source DB:  PubMed          Journal:  Bull N Y Acad Med        ISSN: 0028-7091


  1 in total

1.  Enumeration of components in complex systems by fluorescence spectrophotometry.

Authors:  G WEBER
Journal:  Nature       Date:  1961-04-01       Impact factor: 49.962

  1 in total
  17 in total

1.  A robust Monte Carlo model for the extraction of biological absorption and scattering in vivo.

Authors:  Janelle E Bender; Karthik Vishwanath; Laura K Moore; J Quincy Brown; Vivide Chang; Gregory M Palmer; Nirmala Ramanujam
Journal:  IEEE Trans Biomed Eng       Date:  2009-04       Impact factor: 4.538

2.  Model-based analysis of reflectance and fluorescence spectra for in vivo detection of cervical dysplasia and cancer.

Authors:  Crystal Redden Weber; Richard A Schwarz; E Neely Atkinson; Dennis D Cox; Calum Macaulay; Michele Follen; Rebecca Richards-Kortum
Journal:  J Biomed Opt       Date:  2008 Nov-Dec       Impact factor: 3.170

3.  Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels.

Authors:  Yang Pu; Jianpeng Xue; Wubao Wang; Baogang Xu; Yueqing Gu; Rui Tang; Ellen Ackerstaff; Jason A Koutcher; Samuel Achilefu; Robert R Alfano
Journal:  J Biomed Opt       Date:  2013-08       Impact factor: 3.170

4.  Detection and evaluation of normal and malignant cells using laser-induced fluorescence spectroscopy.

Authors:  Mohamad E Khosroshahi; Mahya Rahmani
Journal:  J Fluoresc       Date:  2011-09-08       Impact factor: 2.217

5.  Non-invasive, Contrast-enhanced Spectral Imaging of Breast Cancer Signatures in Preclinical Animal Models In vivo.

Authors:  V Krishnan Ramanujan; Songyang Ren; Sangyong Park; Daniel L Farkas
Journal:  J Cell Sci Ther       Date:  2010-10-02

6.  Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules.

Authors:  Bidyut Das; Lingyan Shi; Yury Budansky; Adrian Rodriguez-Contreras; Robert Alfano
Journal:  J Biophotonics       Date:  2017-05-02       Impact factor: 3.207

7.  Nucleotide excision repair is reduced in oral epithelial tissues compared with skin.

Authors:  David Mitchell; Lakshmi Paniker; Dianne Godar
Journal:  Photochem Photobiol       Date:  2012-06-01       Impact factor: 3.421

8.  Early detection of premalignant changes in cell cultures using light-induced fluorescence spectroscopy.

Authors:  E Bogomolny; Shaul Mordechai; A Zwielly; M Huleihel
Journal:  Eur Biophys J       Date:  2009-06-05       Impact factor: 1.733

9.  Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach.

Authors:  Changfang Zhu; Gregory M Palmer; Tara M Breslin; Josephine Harter; Nirmala Ramanujam
Journal:  J Biomed Opt       Date:  2008 May-Jun       Impact factor: 3.170

10.  Model based and empirical spectral analysis for the diagnosis of breast cancer.

Authors:  Changfang Zhu; Tara M Breslin; Josephine Harter; Nirmala Ramanujam
Journal:  Opt Express       Date:  2008-09-15       Impact factor: 3.894

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