| Literature DB >> 20472430 |
Tao Li1, William H Bunnelle, Keith B Ryther, David J Anderson, John Malysz, Rosalind Helfrich, Jens H Grønlien, Monika Håkerud, Dan Peters, Michael R Schrimpf, Murali Gopalakrishnan, Jianguo Ji.
Abstract
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent alpha7 NNR agonist activity. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20472430 DOI： 10.1016/j.bmcl.2010.04.105
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823