Literature DB >> 2046658

New classes of Streptomyces coelicolor A3(2) mutants blocked in undecylprodigiosin (Red) biosynthesis.

E A Coco1, K E Narva, J S Feitelson.   

Abstract

Fifteen mutants of Streptomyces coelicolor A3(2) blocked in both the bipyrrole branch (redA) and a second site specific to the undecylprodigiosin pathway were characterized. Some of the mutants were ordered biosynthetically based on cosynthesis experiments. Complementation of each of the mutants with wild-type DNA cloned in low- and high-copy number plasmid vectors allowed the mutants to be separated into 12 new classes which are physically clustered within approximately 37 kb on the S. coelicolor genome. Early-step biosynthetic genes are centrally located and are flanked by later-step and regulatory genes.

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Year:  1991        PMID： 2046658     DOI： 10.1007/bf00260702

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  12 in total

1.  Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2).

Authors:  F Malpartida; D A Hopwood
Journal:  Mol Gen Genet       Date:  1986-10

2.  Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives.

Authors:  S W Tsao; B A Rudd; X G He; C J Chang; H G Floss
Journal:  J Antibiot (Tokyo)       Date:  1985-01       Impact factor: 2.649

3.  Cloning and expression in a heterologous host of the complete set of genes for biosynthesis of the Streptomyces coelicolor antibiotic undecylprodigiosin.

Authors:  F Malpartida; J Niemi; R Navarrete; D A Hopwood
Journal:  Gene       Date:  1990-09-01       Impact factor: 3.688

4.  A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster.

Authors:  B A Rudd; D A Hopwood
Journal:  J Gen Microbiol       Date:  1980-08

5.  Cloning of a Streptomyces gene for an O-methyltransferase involved in antibiotic biosynthesis.

Authors:  J S Feitelson; D A Hopwood
Journal:  Mol Gen Genet       Date:  1983

6.  Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2).

Authors:  K E Narva; J S Feitelson
Journal:  J Bacteriol       Date:  1990-01       Impact factor: 3.490

7.  Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

Authors:  H Motamedi; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

8.  The Streptomyces plasmid SCP2*: its functional analysis and development into useful cloning vectors.

Authors:  D J Lydiate; F Malpartida; D A Hopwood
Journal:  Gene       Date:  1985       Impact factor: 3.688

9.  Genetic and biochemical characterization of the red gene cluster of Streptomyces coelicolor A3(2).

Authors:  J S Feitelson; F Malpartida; D A Hopwood
Journal:  J Gen Microbiol       Date:  1985-09

10.  Molecular genetics of Red biosynthesis in Streptomyces.

Authors:  J S Feitelson; A M Sinha; E A Coco
Journal:  J Nat Prod       Date:  1986 Nov-Dec       Impact factor: 4.050
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  9 in total

1.  Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.

Authors:  Dong-Jin Kim; Jung-Hyun Huh; Young-Yell Yang; Choong-Min Kang; In-Hyung Lee; Chang-Gu Hyun; Soon-Kwang Hong; Joo-Won Suh
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

2.  Genome sequence of the cycloprodigiosin-producing bacterial strain Pseudoalteromonas rubra ATCC 29570(T).

Authors:  Bin-Bin Xie; Yan-Li Shu; Qi-Long Qin; Jin-Cheng Rong; Xi-Ying Zhang; Xiu-Lan Chen; Bai-Cheng Zhou; Yu-Zhong Zhang
Journal:  J Bacteriol       Date:  2012-03       Impact factor: 3.490

3.  bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade.

Authors:  J White; M Bibb
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

4.  Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp.

Authors:  Ramón I Santamaría; Ana Martínez-Carrasco; Jesús Martín; José R Tormo; Ignacio Pérez-Victoria; Ignacio González; Olga Genilloud; Fernando Reyes; Margarita Díaz
Journal:  Antibiotics (Basel)       Date:  2022-05-17

5.  Transcriptional regulation of Streptomyces coelicolor pathway-specific antibiotic regulators by the absA and absB loci.

Authors:  D J Aceti; W C Champness
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

6.  Genetically modified bacterial strains and novel bacterial artificial chromosome shuttle vectors for constructing environmental libraries and detecting heterologous natural products in multiple expression hosts.

Authors:  Asuncion Martinez; Steven J Kolvek; Choi Lai Tiong Yip; Joern Hopke; Kara A Brown; Ian A MacNeil; Marcia S Osburne
Journal:  Appl Environ Microbiol       Date:  2004-04       Impact factor: 4.792

Review 7.  Prodigiosin and its potential applications.

Authors:  N Darshan; H K Manonmani
Journal:  J Food Sci Technol       Date:  2015-01-24       Impact factor: 2.701

8.  The two kinases, AbrC1 and AbrC2, of the atypical two-component system AbrC are needed to regulate antibiotic production and differentiation in Streptomyces coelicolor.

Authors:  Héctor Rodríguez; Sergio Rico; Ana Yepes; Elsa Franco-Echevarría; Sergio Antoraz; Ramón I Santamaría; Margarita Díaz
Journal:  Front Microbiol       Date:  2015-05-12       Impact factor: 5.640

9.  The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces.

Authors:  Ramón I Santamaría; Laura Sevillano; Jesús Martín; Olga Genilloud; Ignacio González; Margarita Díaz
Journal:  Front Microbiol       Date:  2018-11-16       Impact factor: 5.640
  9 in total

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