| Literature DB >> 20458547 |
Ismiarni Komala1, Takuya Ito, Fumihiro Nagashima, Yasuyuki Yagi, Yoshinori Asakawa.
Abstract
A drimane, (+)-drimenol (1), five known herbertanes, (-)-alpha-herbertenol (2), (-)-herbertenediol (3), mastigophorene A (4), (-)-mastigophorene C (5) and (-)-mastigophorene D (6), a pimarane, (-)-ent-pimara-8(14),15-dien-19-oic acid (7), and two eudesmanolides, (-)-diplophyllolide A (8) and (-)-diplophyllin (9) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes (2, 3, 5 and 6) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis. (-)-Diplophyllolide A (8) also exhibited cytotoxicity against HL-60 and KB cell lines.Entities:
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Year: 2010 PMID: 20458547 DOI: 10.1007/s11418-010-0423-8
Source DB: PubMed Journal: J Nat Med ISSN: 1340-3443 Impact factor: 2.343