Diplophyllolide: a cytotoxic sesquiterpene lactone from the liverworts Clasmatocolea vermicularis and Chiloscyphus subporosa.

A bioactivity-directed investigation of a New Zealand collection of the liverwort Clasmatocolea vermicularis led to the isolation of the sesquiterpene lactone, diplophyllolide [1], as the major cytotoxic component. The cytotoxic extract of another liverwort, Chiloscyphus subporosa, also contained diplophyllolide.