Literature DB >> 20453839

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.

Amy L Sherborne1, Fay J Hosking, Rashmi B Prasad, Rajiv Kumar, Rolf Koehler, Jayaram Vijayakrishnan, Elli Papaemmanuil, Claus R Bartram, Martin Stanulla, Martin Schrappe, Andreas Gast, Sara E Dobbins, Yussanne Ma, Eamonn Sheridan, Malcolm Taylor, Sally E Kinsey, Tracey Lightfoot, Eve Roman, Julie A E Irving, James M Allan, Anthony V Moorman, Christine J Harrison, Ian P Tomlinson, Sue Richards, Martin Zimmermann, Csaba Szalai, Agnes F Semsei, Daniel J Erdelyi, Maja Krajinovic, Daniel Sinnett, Jasmine Healy, Anna Gonzalez Neira, Norihiko Kawamata, Seishi Ogawa, H Phillip Koeffler, Kari Hemminki, Mel Greaves, Richard S Houlston.   

Abstract

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

Entities:  

Mesh：

Year:  2010        PMID： 20453839      PMCID： PMC3434228          DOI： 10.1038/ng.585

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

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  121 in total

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