UNLABELLED: Despite adolescent black females experiencing the highest rates of obesity, the effect of excess fat mass on bone structure and strength in this population is unknown. Our findings in postadolescent black females suggest that excess weight in the form of fat mass may adversely influence cortical bone structure and strength. INTRODUCTION: Although adolescent obesity has been associated with reduced bone structure and strength in white females, this relationship has not been studied in adolescent black females, a population experiencing the highest rates of obesity. Our objective was to compare bone structure and strength between postadolescent black females with normal and high levels of adiposity. METHODS: Black females with ≤ 32% body fat were classified as normal body fat (NF; n = 33, aged 19.3 ± 1.3 years); females exceeding this cutoff were classified as high body fat (HF; n = 15, aged 19.0 ± 1.1 years). Using peripheral quantitative computed tomography, tibial and radial bones were scanned at the 4% (trabecular) and 20% (cortical) sites from the distal metaphyses. Fat-free soft-tissue mass (FFST) and %body fat were assessed by dual-energy X-ray absorptiometry. RESULTS: After controlling for either FFST or body weight, the HF vs. NF group had lower total cross-sectional area (CSA; 9-17%), cortical CSA (6-15%), and strength-strain index (SSI; 13-24%) at the cortical site of the tibia (all p < 0.05). At the cortical site of the radius, the HF vs. NF group had lower total CSA (14%, p = 0.03), cortical CSA (9%, p = 0.04), and SSI (15%, p = 0.07) after control for body weight. There were no group differences in either the FFST-adjusted cortical bone values at the radius or in the trabecular bone parameters (body weight- or FFST-adjusted) at the tibia and radius. CONCLUSIONS: Consistent with our adiposity and bone data in late-adolescent white females, our findings in black females entering adulthood also suggest that obesity may adversely influence cortical bone strength.
UNLABELLED: Despite adolescent black females experiencing the highest rates of obesity, the effect of excess fat mass on bone structure and strength in this population is unknown. Our findings in postadolescent black females suggest that excess weight in the form of fat mass may adversely influence cortical bone structure and strength. INTRODUCTION: Although adolescent obesity has been associated with reduced bone structure and strength in white females, this relationship has not been studied in adolescent black females, a population experiencing the highest rates of obesity. Our objective was to compare bone structure and strength between postadolescent black females with normal and high levels of adiposity. METHODS: Black females with ≤ 32% body fat were classified as normal body fat (NF; n = 33, aged 19.3 ± 1.3 years); females exceeding this cutoff were classified as high body fat (HF; n = 15, aged 19.0 ± 1.1 years). Using peripheral quantitative computed tomography, tibial and radial bones were scanned at the 4% (trabecular) and 20% (cortical) sites from the distal metaphyses. Fat-free soft-tissue mass (FFST) and %body fat were assessed by dual-energy X-ray absorptiometry. RESULTS: After controlling for either FFST or body weight, the HF vs. NF group had lower total cross-sectional area (CSA; 9-17%), cortical CSA (6-15%), and strength-strain index (SSI; 13-24%) at the cortical site of the tibia (all p < 0.05). At the cortical site of the radius, the HF vs. NF group had lower total CSA (14%, p = 0.03), cortical CSA (9%, p = 0.04), and SSI (15%, p = 0.07) after control for body weight. There were no group differences in either the FFST-adjusted cortical bone values at the radius or in the trabecular bone parameters (body weight- or FFST-adjusted) at the tibia and radius. CONCLUSIONS: Consistent with our adiposity and bone data in late-adolescent white females, our findings in black females entering adulthood also suggest that obesity may adversely influence cortical bone strength.
Authors: Christopher R McCartney; Susan K Blank; Kathleen A Prendergast; Sandhya Chhabra; Christine A Eagleson; Kristin D Helm; Richard Yoo; R Jeffrey Chang; Carol M Foster; Sonia Caprio; John C Marshall Journal: J Clin Endocrinol Metab Date: 2006-11-21 Impact factor: 5.958
Authors: Gordon L Klein; Lorraine A Fitzpatrick; Craig B Langman; Thomas J Beck; Thomas O Carpenter; Vicente Gilsanz; Ingrid A Holm; Mary B Leonard; Bonny L Specker Journal: J Bone Miner Res Date: 2005-09-06 Impact factor: 6.741
Authors: Erica D Taylor; Kelly R Theim; Margaret C Mirch; Samareh Ghorbani; Marian Tanofsky-Kraff; Diane C Adler-Wailes; Sheila Brady; James C Reynolds; Karim A Calis; Jack A Yanovski Journal: Pediatrics Date: 2006-06 Impact factor: 7.124
Authors: Alexandra Ackerman; John C Thornton; Jack Wang; Richard N Pierson; Mary Horlick Journal: Obesity (Silver Spring) Date: 2006-05 Impact factor: 5.002
Authors: Thomas J Beck; Moira A Petit; Guanglin Wu; Meryl S LeBoff; Jane A Cauley; Zhao Chen Journal: J Bone Miner Res Date: 2009-08 Impact factor: 6.741
Authors: K O Klein; K A Larmore; E de Lancey; J M Brown; R V Considine; S G Hassink Journal: J Clin Endocrinol Metab Date: 1998-10 Impact factor: 5.958
Authors: Norman K Pollock; Paul J Bernard; Karl Wenger; Sudipta Misra; Barbara A Gower; Jerry D Allison; Haidong Zhu; Catherine L Davis Journal: J Bone Miner Res Date: 2010-07-16 Impact factor: 6.741
Authors: Joseph M Kindler; Norman K Pollock; Hannah L Ross; Christopher M Modlesky; Harshvardhan Singh; Emma M Laing; Richard D Lewis Journal: Calcif Tissue Int Date: 2017-07-14 Impact factor: 4.333
Authors: Norman K Pollock; Paul J Bernard; Bernard Gutin; Catherine L Davis; Haidong Zhu; Yanbin Dong Journal: J Pediatr Date: 2011-01-13 Impact factor: 4.406
Authors: Emma M Laing; Ralph A Tripp; Norman K Pollock; Clifton A Baile; Mary Anne Della-Fera; Srujana Rayalam; Stephen M Tompkins; Deborah A Keys; Richard D Lewis Journal: J Bone Miner Res Date: 2013-03 Impact factor: 6.741
Authors: Mary B Leonard; Babette S Zemel; Brian H Wrotniak; Sarah B Klieger; Justine Shults; Virginia A Stallings; Nicolas Stettler Journal: Bone Date: 2014-12-10 Impact factor: 4.398