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Literature DB >> 20449263

Enzymatic activation of a matrix metalloproteinase inhibitor.

Abstract

Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase.

Entities: Chemical Disease Species

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Year: 2010 PMID： 20449263 PMCID： PMC2867072 DOI： 10.1039/b923302d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

32 in total

1. Design and therapeutic application of matrix metalloproteinase inhibitors.

Authors: M Whittaker; C D Floyd; P Brown; A J Gearing
Journal: Chem Rev Date: 1999-09-08 Impact factor: 60.622

2. Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.

Authors: Giuseppina De Simone; Rosa Maria Vitale; Anna Di Fiore; Carlo Pedone; Andrea Scozzafava; Jean-Louis Montero; Jean-Yves Winum; Claudiu T Supuran
Journal: J Med Chem Date: 2006-09-07 Impact factor: 7.446

3. Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.

Authors: Takayoshi Suzuki; Shinya Hisakawa; Yukihiro Itoh; Nobuaki Suzuki; Katsumasa Takahashi; Masatoshi Kawahata; Kentaro Yamaguchi; Hidehiko Nakagawa; Naoki Miyata
Journal: Bioorg Med Chem Lett Date: 2007-05-17 Impact factor: 2.823

Review 4. MMPs as therapeutic targets--still a viable option?

Authors: Barbara Fingleton
Journal: Semin Cell Dev Biol Date: 2007-07-06 Impact factor: 7.727

5. Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix--cell signaling during bronchiole branching morphogenesis.

Authors: Sean E Gill; M Cynthia Pape; Kevin J Leco
Journal: Dev Biol Date: 2006-07-12 Impact factor: 3.582

6. Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) beta-glucuronide and beta-galactoside for application in selective prodrug chemotherapy.

Authors: Mickaël Thomas; Freddy Rivault; Isabelle Tranoy-Opalinski; Joëlle Roche; Jean-Pierre Gesson; Sébastien Papot
Journal: Bioorg Med Chem Lett Date: 2006-11-17 Impact factor: 2.823

Review 7. Strategies for MMP inhibition in cancer: innovations for the post-trial era.

Authors: Christopher Mark Overall; Carlos López-Otín
Journal: Nat Rev Cancer Date: 2002-09 Impact factor: 60.716

8. A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.

Authors: C G Knight; F Willenbrock; G Murphy
Journal: FEBS Lett Date: 1992-01-27 Impact factor: 4.124

9. New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups.

Authors: David T Puerta; Jana A Lewis; Seth M Cohen
Journal: J Am Chem Soc Date: 2004-07-14 Impact factor: 15.419

10. Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

Authors: Tim Storr; Michael Merkel; George X Song-Zhao; Lauren E Scott; David E Green; Meryn L Bowen; Katherine H Thompson; Brian O Patrick; Harvey J Schugar; Chris Orvig
Journal: J Am Chem Soc Date: 2007-05-19 Impact factor: 15.419

5 in total

5. The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme.

Authors: Yasuhiro Tsume; Gordon L Amidon
Journal: Molecules Date: 2012-03-26 Impact factor: 4.411