Literature DB >> 17532630

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.

Takayoshi Suzuki1, Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa, Naoki Miyata.   

Abstract

Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of 1 was significantly reduced by free folic acid, suggesting that cellular uptake of 1 is mediated by FR.

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Year:  2007        PMID： 17532630     DOI： 10.1016/j.bmcl.2007.05.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Enzymatic activation of a matrix metalloproteinase inhibitor.

Authors:  Jody L Major Jourden; Seth M Cohen
Journal:  Chem Commun (Camb)       Date:  2010-01-18       Impact factor: 6.222

2.  Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.

Authors:  Quaovi H Sodji; James R Kornacki; John F McDonald; Milan Mrksich; Adegboyega K Oyelere
Journal:  Eur J Med Chem       Date:  2015-04-08       Impact factor: 6.514

3.  Folate-targeted nanoparticles based on albumin and albumin/alginate mixtures as controlled release systems of tamoxifen: synthesis and in vitro characterization.

Authors:  A Martínez; R Olmo; I Iglesias; J M Teijón; M D Blanco
Journal:  Pharm Res       Date:  2013-08-07       Impact factor: 4.200

4.  Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation.

Authors:  Pavel I Kitov; Eugenia Paszkiewicz; Joanna M Sadowska; Zhicheng Deng; Marya Ahmed; Ravin Narain; Thomas P Griener; George L Mulvey; Glen D Armstrong; David R Bundle
Journal:  Toxins (Basel)       Date:  2011-08-25       Impact factor: 4.546

5.  Thiazole formation through a modified Gewald reaction.

Authors:  Carl J Mallia; Lukas Englert; Gary C Walter; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2015-05-26       Impact factor: 2.883

6.  Ricolinostat, a selective HDAC6 inhibitor, shows anti-lymphoma cell activity alone and in combination with bendamustine.

Authors:  Maria Cosenza; Monica Civallero; Luigi Marcheselli; Stefano Sacchi; Samantha Pozzi
Journal:  Apoptosis       Date:  2017-06       Impact factor: 4.677

Review 7.  HDAC Inhibitors: Innovative Strategies for Their Design and Applications.

Authors:  Mateusz Daśko; Beatriz de Pascual-Teresa; Irene Ortín; Ana Ramos
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

8.  A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes.

Authors:  Carlotta Figliola; Estelle Marchal; Brandon R Groves; Alison Thompson
Journal:  RSC Adv       Date:  2019-05-07       Impact factor: 4.036

9.  Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents.

Authors:  Juliusz Maksymilian Walczak; Dorota Iwaszkiewicz-Grześ; Michalina Ziomkowska; Magdalena Śliwka-Kaszyńska; Mateusz Daśko; Piotr Trzonkowski; Grzegorz Cholewiński
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

Review 10.  Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review.

Authors:  Claudia Marchetti; Innocenza Palaia; Margherita Giorgini; Caterina De Medici; Roberta Iadarola; Laura Vertechy; Lavinia Domenici; Violante Di Donato; Federica Tomao; Ludovico Muzii; Pierluigi Benedetti Panici
Journal:  Onco Targets Ther       Date:  2014-07-10       Impact factor: 4.147
  10 in total

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