Literature DB >> 20435480

Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives.

Omaima M Abdelhafez1, Kamelia M Amin, Rasha Z Batran, Timothy J Maher, Somaia A Nada, Shalini Sethumadhavan.   

Abstract

The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20435480     DOI： 10.1016/j.bmc.2010.04.009

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

Review 1.  The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions.

Authors:  Ghodsi Mohammadi Ziarani; Razieh Moradi; Tahereh Ahmadi; Parisa Gholamzadeh
Journal:  Mol Divers       Date:  2019-01-29       Impact factor: 2.943

2.  Influence of kidney function on risk of supratherapeutic international normalized ratio-related hemorrhage in warfarin users: a prospective cohort study.

Authors:  Nita A Limdi; Thomas D Nolin; Sarah L Booth; Amanda Centi; Marisa B Marques; Michael R Crowley; Michael Allon; T Mark Beasley
Journal:  Am J Kidney Dis       Date:  2014-11-25       Impact factor: 8.860

3.  4-[(E)-(4-Hy-droxy-2-oxo-2H-chromen-3-yl)methyl-idene-amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one monohydrate.

Authors:  Mohammad Asad; Chuan-Wei Oo; Hasnah Osman; Ching Kheng Quah; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-04

4.  4-Hy-droxy-3-[(4-hy-droxy-2-oxo-2H-3-chromen-yl)(3-thien-yl)meth-yl]-2H-chromen-2-one.

Authors:  Mohammad Asad; Chuan-Wei Oo; Hasnah Osman; Mohd Mustaqim Rosli; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-04-07

5.  One-Pot Syntesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions.

Authors:  Yang Gao; Guo-Ning Zhang; Juxian Wang; Xiaoguang Bai; Yiliang Li; Yucheng Wang
Journal:  Molecules       Date:  2018-01-22       Impact factor: 4.411

6.  Angiotensin-I-Converting Enzyme Inhibitory Activity of Coumarins from Angelica decursiva.

Authors:  Md Yousof Ali; Su Hui Seong; Hyun Ah Jung; Jae Sue Choi
Journal:  Molecules       Date:  2019-10-31       Impact factor: 4.411

7.  Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation.

Authors:  Victor Kartsev; Athina Geronikaki; Silvia Bua; Alessio Nocentini; Anthi Petrou; Boris Lichitsky; Mykhaylo Frasinyuk; Janis Leitans; Andris Kazaks; Kaspars Tars; Claudiu T Supuran
Journal:  Molecules       Date:  2019-10-04       Impact factor: 4.411

Review 8.  An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents.

Authors:  Laila Rubab; Sumbal Afroz; Sajjad Ahmad; Saddam Hussain; Iram Nawaz; Ali Irfan; Fozia Batool; Katarzyna Kotwica-Mojzych; Mariusz Mojzych
Journal:  Molecules       Date:  2022-02-28       Impact factor: 4.411

Review 9.  Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds.

Authors:  Angela Stefanachi; Francesco Leonetti; Leonardo Pisani; Marco Catto; Angelo Carotti
Journal:  Molecules       Date:  2018-01-27       Impact factor: 4.411

Review 10.  Antagonists of Vitamin K-Popular Coumarin Drugs and New Synthetic and Natural Coumarin Derivatives.

Authors:  Kinga Kasperkiewicz; Michał B Ponczek; Jacek Owczarek; Piotr Guga; Elżbieta Budzisz
Journal:  Molecules       Date:  2020-03-24       Impact factor: 4.411
  10 in total

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