| Literature DB >> 20430728 |
Bozena Dobrzycka1, Slawomir J Terlikowski, Magdalena Garbowicz, Wieslawa Niklińska, Piotr S Bernaczyk, Jacek Nikliński, Maciej Kinalski, Lech Chyczewski.
Abstract
The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.Entities:
Mesh：
Substances：
Year: 2009 PMID： 20430728 DOI： 10.2478/v10042-008-0117-1
Source DB: PubMed Journal: Folia Histochem Cytobiol ISSN： 0239-8508 Impact factor: 1.698