| Literature DB >> 29802567 |
Rosekeila Simões Nomelini1, Luciano Eliziário Borges Júnior2, Cid Almeida de Lima2, Ana Flávia Carrijo Chiovato2, Douglas Côbo Micheli3, Beatriz Martins Tavares-Murta3, Eddie Fernando Candido Murta2.
Abstract
The aims of the study were to compare the levels of tumor necrosis factor alpha (TNF-α) and its soluble type I (sTNF-R1) and type II (sTNF-R2) receptors detected in intracystic liquid and serum from benign and malignant ovarian neoplasms and to relate them to prognostic factors in epithelial ovarian cancer. The patients were divided into benign ovarian neoplasms (n = 46) and malignant ovarian neoplasms (n = 17). The serum and intracystic samples were collected before and during surgery for ovarian cyst, respectively. The levels of TNF-α, sTNF-R1, and sTNF-R2 were measured using ELISA. Results were compared with the Mann-Whitney test. Concentration of sTNF-R2 in the intracystic samples collected from the malignant neoplasia was significantly higher than that of the benign neoplasias (p = 0.02). Higher intracystic levels of sTNF-R2 exhibited a significant association with tumor differentiation grades 2 and 3 (p = 0.0087). There was no statistical significance in relation to serum levels. Tumor microenvironment levels of sTNF-R2 may represent a factor of poor prognosis in epithelial ovarian cancer.Entities:
Keywords: Intracystic fluid; Ovarian neoplasm; Prognostic factor; Tumor necrosis factor alpha; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor 2
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Year: 2018 PMID： 29802567 DOI： 10.1007/s10238-018-0508-3
Source DB: PubMed Journal: Clin Exp Med ISSN： 1591-8890 Impact factor: 3.984