Literature DB >> 20420436

Global sensitivity analysis for systems with independent and/or correlated inputs.

Genyuan Li1, Herschel Rabitz, Paul E Yelvington, Oluwayemisi O Oluwole, Fred Bacon, Charles E Kolb, Jacqueline Schoendorf.   

Abstract

The objective of a global sensitivity analysis is to rank the importance of the system inputs considering their uncertainty and the influence they have upon the uncertainty of the system output, typically over a large region of input space. This paper introduces a new unified framework of global sensitivity analysis for systems whose input probability distributions are independent and/or correlated. The new treatment is based on covariance decomposition of the unconditional variance of the output. The treatment can be applied to mathematical models, as well as to measured laboratory and field data. When the input probability distribution is correlated, three sensitivity indices give a full description, respectively, of the total, structural (reflecting the system structure) and correlative (reflecting the correlated input probability distribution) contributions for an input or a subset of inputs. The magnitudes of all three indices need to be considered in order to quantitatively determine the relative importance of the inputs acting either independently or collectively. For independent inputs, these indices reduce to a single index consistent with previous variance-based methods. The estimation of the sensitivity indices is based on a meta-modeling approach, specifically on the random sampling-high dimensional model representation (RS-HDMR). This approach is especially useful for the treatment of laboratory and field data where the input sampling is often uncontrolled.

Entities:  

Year:  2010        PMID: 20420436     DOI: 10.1021/jp9096919

Source DB:  PubMed          Journal:  J Phys Chem A        ISSN: 1089-5639            Impact factor:   2.781


  21 in total

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7.  Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway.

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Journal:  Comput Chem Eng       Date:  2014-12-04       Impact factor: 3.845

8.  Hierarchical cluster-based partial least squares regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models.

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Journal:  BMC Syst Biol       Date:  2011-06-01

9.  Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR).

Authors:  Miles A Miller; Xiao-Jiang Feng; Genyuan Li; Herschel A Rabitz
Journal:  PLoS One       Date:  2012-06-18       Impact factor: 3.240

10.  A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.

Authors:  Alexander D Malkin; Robert P Sheehan; Shibin Mathew; William J Federspiel; Heinz Redl; Gilles Clermont
Journal:  PLoS Comput Biol       Date:  2015-10-15       Impact factor: 4.475

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