| Literature DB >> 20418489 |
Lu Qi1, Marilyn C Cornelis, Peter Kraft, Kristopher J Stanya, W H Linda Kao, James S Pankow, Josée Dupuis, Jose C Florez, Caroline S Fox, Guillaume Paré, Qi Sun, Cynthia J Girman, Cathy C Laurie, Daniel B Mirel, Teri A Manolio, Daniel I Chasman, Eric Boerwinkle, Paul M Ridker, David J Hunter, James B Meigs, Chih-Hao Lee, Frank B Hu, Rob M van Dam.
Abstract
To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8)). The frequency of the risk-lowering allele T is 0.23. Variants in this region were nominally related to lower fasting glucose and HOMA-IR in the MAGIC consortium (P<0.05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.Entities:
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Year: 2010 PMID： 20418489 PMCID： PMC2883345 DOI： 10.1093/hmg/ddq156
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150