Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

Literature DB >> 2041734

Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

M North¹, C Sargent, J O'Brien, K Taylor, J Wolfe, N A Affara, M A Ferguson-Smith.

Abstract

We have cloned and sequenced transcripts from the X- and Y-linked zinc-finger genes ZFX and ZFY respectively and discuss a possible mechanism of post-transcriptional control by which these genes can be widely expressed but translated in only specific tissues. We report the identification of a novel 3'UTR (untranslated region) present in ZFY which is highly conserved among primates and contains a series of motifs implicated as mRNA instability determinants. These sequences can be substantially removed by polyadenylation directed from consensus (AATAAA) and non-consensus (AATATAAA) sequences in adult testis. The DNA-binding domains of the ZFY and ZFX proteins are compared using present models for zinc-finger/DNA interactions. Additionally, the genomic organisation of the ZFY coding sequence is presented as compared to that of ZFX.

Entities: Gene

Mesh：

Substances：
DNA

Year: 1991 PMID： 2041734 PMCID： PMC328173 DOI： 10.1093/nar/19.10.2579

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

24 in total

1. Comparison of human ZFY and ZFX transcripts.

Authors: M S Palmer; P Berta; A H Sinclair; B Pym; P N Goodfellow
Journal: Proc Natl Acad Sci U S A Date: 1990-03 Impact factor: 11.205

2. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.

Authors: G Mardon; S W Luoh; E M Simpson; G Gill; L G Brown; D C Page
Journal: Mol Cell Biol Date: 1990-02 Impact factor: 4.272

3. Genetic evidence that ZFY is not the testis-determining factor.

Authors: M S Palmer; A H Sinclair; P Berta; N A Ellis; P N Goodfellow; N E Abbas; M Fellous
Journal: Nature Date: 1989 Dec 21-28 Impact factor: 49.962

4. Three-dimensional solution structure of a single zinc finger DNA-binding domain.

Authors: M S Lee; G P Gippert; K V Soman; D A Case; P E Wright
Journal: Science Date: 1989-08-11 Impact factor: 47.728

5. Putative transcription activator with alternative isoforms encoded by human ZFX gene.

Authors: A Schneider-Gädicke; P Beer-Romero; L G Brown; G Mardon; S W Luoh; D C Page
Journal: Nature Date: 1989-12-07 Impact factor: 49.962

6. Translational blockade imposed by cytokine-derived UA-rich sequences.

Authors: V Kruys; O Marinx; G Shaw; J Deschamps; G Huez
Journal: Science Date: 1989-08-25 Impact factor: 47.728

7. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.

Authors: Y F Lau; K M Chan
Journal: Am J Hum Genet Date: 1989-12 Impact factor: 11.025

8. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues.

Authors: C M Nagamine; K Chan; L E Hake; Y F Lau
Journal: Genes Dev Date: 1990-01 Impact factor: 11.361

9. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.

Authors: A H Sinclair; P Berta; M S Palmer; J R Hawkins; B L Griffiths; M J Smith; J W Foster; A M Frischauf; R Lovell-Badge; P N Goodfellow
Journal: Nature Date: 1990-07-19 Impact factor: 49.962

10. Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.

Authors: P Koopman; J Gubbay; J Collignon; R Lovell-Badge
Journal: Nature Date: 1989 Dec 21-28 Impact factor: 49.962

9 in total

1. Knockdown of zinc finger protein, X-linked (ZFX) inhibits cell proliferation and induces apoptosis in human laryngeal squamous cell carcinoma.

Authors: Jugao Fang; Zhenkun Yu; Meng Lian; Hongzhi Ma; Jun Tai; Luo Zhang; Demin Han
Journal: Mol Cell Biochem Date: 2011-10-19 Impact factor: 3.396

2. Potential problems in estimating the male-to-female mutation rate ratio from DNA sequence data.

Authors: L C Shimmin; B H Chang; D Hewett-Emmett; W H Li
Journal: J Mol Evol Date: 1993-08 Impact factor: 2.395

3. RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.

Authors: YongSheng Zhang; JiFeng Xi; Bin Jia; XiangZu Wang; XuHai Wang; ChaoCheng Li; YaQiang Li; XianCun Zeng; RuiWen Ying; Xin Li; Song Jiang; FangYuan Yuan
Journal: Mamm Genome Date: 2017-03-01 Impact factor: 2.957

4. An X-linked zinc finger gene mapping to Xq21.1-q21.3 closely related to ZFX and ZFY: possible origins from a common ancestral gene.

Authors: S L Lloyd; C A Sargent; J Chalmers; E Lim; S S Habeebu; N A Affara
Journal: Nucleic Acids Res Date: 1991-09-25 Impact factor: 16.971

5. An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13.

Authors: T C Schulz; B Hopwood; P D Rathjen; J R Wells
Journal: Biochem J Date: 1995-10-01 Impact factor: 3.857

6. Complex genetic counseling and exclusion of Duchenne muscular dystrophy in a twin pregnancy after in vitro fertilization (IVF).

Authors: T H Bui; M Anvret; N Dahl; L Garoff; P Sjöblom; T Hillensjö
Journal: J Assist Reprod Genet Date: 1994-03 Impact factor: 3.412

7. The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.

Authors: Xiaoguang Fang; Zhi Huang; Wenchao Zhou; Qiulian Wu; Andrew E Sloan; Gaoliang Ouyang; Roger E McLendon; Jennifer S Yu; Jeremy N Rich; Shideng Bao
Journal: Stem Cells Date: 2014-08 Impact factor: 6.277

8. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.

Authors: Fanny Decarpentrie; Nadège Vernet; Shantha K Mahadevaiah; Guy Longepied; Eric Streichemberger; Isabelle Aknin-Seifer; Obah A Ojarikre; Paul S Burgoyne; Catherine Metzler-Guillemain; Michael J Mitchell
Journal: Hum Mol Genet Date: 2012-03-09 Impact factor: 6.150

9. The Use of RNAi Technology to Interfere with Zfx Gene Increases the Male Rates of Red Deer (Cervus elaphus) Offspring.

Authors: Limin Wei; Jifeng Xi; Yongsheng Zhang; Bo Zeng; Feng Li; Kaisheng Wang; Siyuan Zhang; Xitang Zhao; Ying Li; Hong Shen; Song Jiang; Bin Jia
Journal: Biomed Res Int Date: 2020-05-18 Impact factor: 3.411

9 in total