| Literature DB >> 1695712 |
A H Sinclair1, P Berta, M S Palmer, J R Hawkins, B L Griffiths, M J Smith, J W Foster, A M Frischauf, R Lovell-Badge, P N Goodfellow.
Abstract
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.Entities:
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Year: 1990 PMID： 1695712 DOI： 10.1038/346240a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962