Literature DB >> 2672333

Translational blockade imposed by cytokine-derived UA-rich sequences.

V Kruys1, O Marinx, G Shaw, J Deschamps, G Huez.   

Abstract

The messenger RNAs specifying certain proteins involved in the inflammatory response and certain oncoproteins contain a conserved UA-rich sequence in the 3' untranslated region. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, has been shown to destabilize mRNA in some eukaryotes. However, this effect is not seen when mRNAs are transferred to Xenopus oocytes, which made it possible to separate stability from translational regulation. For interferon, granulocyte-macrophage colony-stimulating factor, and c-fos RNAs, the UA-rich sequence was observed to preclude mRNA translation.

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Year:  1989        PMID： 2672333     DOI： 10.1126/science.2672333

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  102 in total

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