BACKGROUND/AIMS: Different etiologies for transient global amnesia (TGA) have been proposed, such as venous flow abnormalities, spreading depression and migraine-related mechanisms like focal ischemia. Jugular vein valve incompetence (JVI) is commonly described in TGA patients, but its contributing role in TGA pathogenesis is still unknown. We investigated the possible relationship between JVI and pathogenetic mechanisms in TGA. METHODS: 243 TGA patients underwent clinical and neurological assessment. Demographic characteristics, TGA-precipitating factors and vascular comorbidities were carefully recorded. In each patient, JVI was assessed by Doppler ultrasonography. RESULTS: TGA patients were grouped according to the presence (n = 171, 70.4%) or absence (n = 72, 29.6%) of JVI. TGA patients with JVI showed a higher presence of precipitating factors, namely a Valsalva-like maneuver (JVI-positive vs. JVI-negative, 35.8 vs. 17.1%, p = 0.004) and emotional stress (36.6 vs. 21.4%, p = 0.023), but had fewer vascular comorbidities, namely hypertension (37.2 vs. 51.4%, p = 0.047) and carotid arteriosclerosis (20.5 vs. 31.9%, p = 0.050). CONCLUSIONS: These findings support the argument for the existence of at least 2 different TGA-associated mechanisms defined by JVI. On the one hand, JVI associated with a Valsalva-like maneuver and emotional stress supported the venous blood congestion hypothesis, and on the other, the JVI-negative group may have another vascular basis, unrelated to venous congestion. (c) 2010 S. Karger AG, Basel.
BACKGROUND/AIMS: Different etiologies for transient global amnesia (TGA) have been proposed, such as venous flow abnormalities, spreading depression and migraine-related mechanisms like focal ischemia. Jugular vein valve incompetence (JVI) is commonly described in TGA patients, but its contributing role in TGA pathogenesis is still unknown. We investigated the possible relationship between JVI and pathogenetic mechanisms in TGA. METHODS: 243 TGA patients underwent clinical and neurological assessment. Demographic characteristics, TGA-precipitating factors and vascular comorbidities were carefully recorded. In each patient, JVI was assessed by Doppler ultrasonography. RESULTS: TGA patients were grouped according to the presence (n = 171, 70.4%) or absence (n = 72, 29.6%) of JVI. TGA patients with JVI showed a higher presence of precipitating factors, namely a Valsalva-like maneuver (JVI-positive vs. JVI-negative, 35.8 vs. 17.1%, p = 0.004) and emotional stress (36.6 vs. 21.4%, p = 0.023), but had fewer vascular comorbidities, namely hypertension (37.2 vs. 51.4%, p = 0.047) and carotid arteriosclerosis (20.5 vs. 31.9%, p = 0.050). CONCLUSIONS: These findings support the argument for the existence of at least 2 different TGA-associated mechanisms defined by JVI. On the one hand, JVI associated with a Valsalva-like maneuver and emotional stress supported the venous blood congestion hypothesis, and on the other, the JVI-negative group may have another vascular basis, unrelated to venous congestion. (c) 2010 S. Karger AG, Basel.
Authors: Fermin Moreno; Gil D Rabinovici; Anna Karydas; Zachary Miller; Sandy Chan Hsu; Andrea Legati; Jamie Fong; Daniel Schonhaut; Hermann Esselmann; Christa Watson; Melanie L Stephens; Joel Kramer; Jens Wiltfang; William W Seeley; Bruce L Miller; Giovanni Coppola; Lea Tenenholz Grinberg Journal: Acta Neuropathol Commun Date: 2015-04-03 Impact factor: 7.801
Authors: Jae-Won Jang; Young Ho Park; So Young Park; Min Jeong Wang; Jae-Sung Lim; Sung-Hun Kim; In KooK Chun; Youngsoon Yang; SangYun Kim Journal: PLoS One Date: 2015-12-21 Impact factor: 3.240
Authors: Erica Menegatti; Mirko Tessari; Sergio Gianesini; Maria Elena Vannini; Francesco Sisini; Paolo Zamboni Journal: Curr Neurovasc Res Date: 2014-05 Impact factor: 1.990
Authors: Anirudh Arun; Matthew R Amans; Nicholas Higgins; Waleed Brinjikji; Mithun Sattur; Sudhakar R Satti; Peter Nakaji; Mark Luciano; Thierry Agm Huisman; Abhay Moghekar; Vitor M Pereira; Ran Meng; Kyle Fargen; Ferdinand K Hui Journal: Neuroradiol J Date: 2021-07-05