AIM: Determine the effect of residual leaning force on intrathoracic pressure (ITP) in healthy children receiving mechanical ventilation. We hypothesized that application of significant residual leaning force (2.5kg or 20% of subject body weight) would be associated with a clinically important change in ITP. METHODS: IRB-approved pilot study of healthy, anesthetized, paralyzed mechanically ventilated children (6 months to 7 years). Peak endotracheal pressure (ETP), a surrogate of ITP, was continuously measured before and during serial incremental increases in sternal force from 10% to 25% of the subject's body weight. A delta ETP of >or=2.0cmH(2)O was considered clinically significant. RESULTS: 13 healthy, anesthetized, paralyzed mechanically ventilated children (age: 26+/-24m, range: 6.5-87m; weight: 13+/-5kg, range: 7.4-24.8kg) were enrolled. Peak ETP increased from baseline for all force applications (10% body weight: mean difference of 0.8cmH(2)O, p<0.01; 15% body weight: mean difference of 1.1cmH(2)O, p<0.01; 20% body weight: mean difference of 1.5cmH(2)O, p<0.01; 25% body weight: mean difference of 1.89cmH(2)O, p<0.01). Residual leaning force of >or=2.5kg was associated with a 2.0cmH(2)O change in peak ETP (odds ratio 7.5; CI(95) 1.5-37.7; p=0.014) while sternal force >or=20% body weight was not (odds ratio 2.4; CI(95) 0.6-9.2; p=0.2). CONCLUSION: In healthy anesthetized children, changes in ETP were detectable at residual leaning forces as low as 10% of subject body weight. Residual leaning force of 2.5kg was associated with increases in ETP >or=2.0cmH(2)O.
AIM: Determine the effect of residual leaning force on intrathoracic pressure (ITP) in healthy children receiving mechanical ventilation. We hypothesized that application of significant residual leaning force (2.5kg or 20% of subject body weight) would be associated with a clinically important change in ITP. METHODS: IRB-approved pilot study of healthy, anesthetized, paralyzed mechanically ventilated children (6 months to 7 years). Peak endotracheal pressure (ETP), a surrogate of ITP, was continuously measured before and during serial incremental increases in sternal force from 10% to 25% of the subject's body weight. A delta ETP of >or=2.0cmH(2)O was considered clinically significant. RESULTS: 13 healthy, anesthetized, paralyzed mechanically ventilated children (age: 26+/-24m, range: 6.5-87m; weight: 13+/-5kg, range: 7.4-24.8kg) were enrolled. Peak ETP increased from baseline for all force applications (10% body weight: mean difference of 0.8cmH(2)O, p<0.01; 15% body weight: mean difference of 1.1cmH(2)O, p<0.01; 20% body weight: mean difference of 1.5cmH(2)O, p<0.01; 25% body weight: mean difference of 1.89cmH(2)O, p<0.01). Residual leaning force of >or=2.5kg was associated with a 2.0cmH(2)O change in peak ETP (odds ratio 7.5; CI(95) 1.5-37.7; p=0.014) while sternal force >or=20% body weight was not (odds ratio 2.4; CI(95) 0.6-9.2; p=0.2). CONCLUSION: In healthy anesthetized children, changes in ETP were detectable at residual leaning forces as low as 10% of subject body weight. Residual leaning force of 2.5kg was associated with increases in ETP >or=2.0cmH(2)O.
Authors: Benjamin S Abella; Jason P Alvarado; Helge Myklebust; Dana P Edelson; Anne Barry; Nicholas O'Hearn; Terry L Vanden Hoek; Lance B Becker Journal: JAMA Date: 2005-01-19 Impact factor: 56.272
Authors: Tom P Aufderheide; Ronald G Pirrallo; Demetris Yannopoulos; John P Klein; Chris von Briesen; Christopher W Sparks; Kimberly A Deja; Craig J Conrad; David J Kitscha; Terry A Provo; Keith G Lurie Journal: Resuscitation Date: 2005-03 Impact factor: 5.262
Authors: Benjamin S Abella; Nathan Sandbo; Peter Vassilatos; Jason P Alvarado; Nicholas O'Hearn; Herbert N Wigder; Paul Hoffman; Kathleen Tynus; Terry L Vanden Hoek; Lance B Becker Journal: Circulation Date: 2005-02-01 Impact factor: 29.690
Authors: Demetris Yannopoulos; Scott McKnite; Tom P Aufderheide; Gardar Sigurdsson; Ronald G Pirrallo; David Benditt; Keith G Lurie Journal: Resuscitation Date: 2005-03 Impact factor: 5.262
Authors: Demetris Yannopoulos; Wanchun Tang; Charis Roussos; Tom P Aufderheide; Ahamed H Idris; Keith G Lurie Journal: Respir Care Date: 2005-05 Impact factor: 2.258
Authors: Mathias Zuercher; Ronald W Hilwig; James Ranger-Moore; Jon Nysaether; Vinay M Nadkarni; Marc D Berg; Karl B Kern; Robert Sutton; Robert A Berg Journal: Crit Care Med Date: 2010-04 Impact factor: 7.598
Authors: Tom P Aufderheide; Gardar Sigurdsson; Ronald G Pirrallo; Demetris Yannopoulos; Scott McKnite; Chris von Briesen; Christopher W Sparks; Craig J Conrad; Terry A Provo; Keith G Lurie Journal: Circulation Date: 2004-04-05 Impact factor: 29.690
Authors: Dana E Niles; Robert M Sutton; Vinay M Nadkarni; Andrew Glatz; Mathias Zuercher; Matthew R Maltese; Joar Eilevstjønn; Benjamin S Abella; Lance B Becker; Robert A Berg Journal: Resuscitation Date: 2011-12 Impact factor: 5.262