Literature DB >> 20407459

The need for precompetitive integrative bionetwork disease model building.

S H Friend1.   

Abstract

If you doubt that there are enormous gaps in the current drug discovery process, you should probably skip to the next article. Yet even while critiques rightly highlight inefficiencies or operational issues, they often miss a fundamental reality: until we better understand diseases as altered bionetworks and view diseases at an individual patient level, efforts to develop effective biomarkers and therapies will be inefficient at best.

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Year:  2010        PMID: 20407459     DOI: 10.1038/clpt.2010.40

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  10 in total

1.  Drug Discovery in Academia- the third way?

Authors:  Julie Frearson; Paul Wyatt
Journal:  Expert Opin Drug Discov       Date:  2010-10-01       Impact factor: 6.098

2.  Developing predictive molecular maps of human disease through community-based modeling.

Authors:  Jonathan M J Derry; Lara M Mangravite; Christine Suver; Matthew D Furia; David Henderson; Xavier Schildwachter; Brian Bot; Jonathan Izant; Solveig K Sieberts; Michael R Kellen; Stephen H Friend
Journal:  Nat Genet       Date:  2012-01-27       Impact factor: 38.330

3.  Counterpoint: Do not opine before it's time.

Authors:  Isaac S Kohane; David M Margulies
Journal:  Nat Biotechnol       Date:  2011-03       Impact factor: 54.908

4.  Point: Are we prepared for the future doctor visit?

Authors:  Stephen H Friend; Trey Ideker
Journal:  Nat Biotechnol       Date:  2011-03       Impact factor: 54.908

Review 5.  Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.

Authors:  Harald Hampel; Nicola Toschi; Claudio Babiloni; Filippo Baldacci; Keith L Black; Arun L W Bokde; René S Bun; Francesco Cacciola; Enrica Cavedo; Patrizia A Chiesa; Olivier Colliot; Cristina-Maria Coman; Bruno Dubois; Andrea Duggento; Stanley Durrleman; Maria-Teresa Ferretti; Nathalie George; Remy Genthon; Marie-Odile Habert; Karl Herholz; Yosef Koronyo; Maya Koronyo-Hamaoui; Foudil Lamari; Todd Langevin; Stéphane Lehéricy; Jean Lorenceau; Christian Neri; Robert Nisticò; Francis Nyasse-Messene; Craig Ritchie; Simone Rossi; Emiliano Santarnecchi; Olaf Sporns; Steven R Verdooner; Andrea Vergallo; Nicolas Villain; Erfan Younesi; Francesco Garaci; Simone Lista
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

Review 6.  Empowering industrial research with shared biomedical vocabularies.

Authors:  Lee Harland; Christopher Larminie; Susanna-Assunta Sansone; Sorana Popa; M Scott Marshall; Michael Braxenthaler; Michael Cantor; Wendy Filsell; Mark J Forster; Enoch Huang; Andreas Matern; Mark Musen; Jasmin Saric; Ted Slater; Jabe Wilson; Nick Lynch; John Wise; Ian Dix
Journal:  Drug Discov Today       Date:  2011-09-23       Impact factor: 7.851

7.  First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium.

Authors:  Laura W Musselwhite; Karolina Maciag; Alex Lankowski; Michael C Gretes; Thomas E Wellems; Gloria Tavera; Rebecca E Goulding; Ethan Guillen
Journal:  Am J Trop Med Hyg       Date:  2012-01       Impact factor: 2.345

Review 8.  Biomarkers of treatment toxicity in combined-modality cancer therapies with radiation and systemic drugs: study design, multiplex methods, molecular networks.

Authors:  Anne Hansen Ree; Sebastian Meltzer; Kjersti Flatmark; Svein Dueland; Erta Kalanxhi
Journal:  Int J Mol Sci       Date:  2014-12-09       Impact factor: 5.923

9.  Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology.

Authors:  Michael K Skinner; Marina I Savenkova; Bin Zhang; Andrea C Gore; David Crews
Journal:  BMC Genomics       Date:  2014-05-16       Impact factor: 3.969

Review 10.  More Haste, Less Speed: Could Public-Private Partnerships Advance Cellular Immunotherapies?

Authors:  Tania Bubela; Katherine Bonter; Silvy Lachance; Jean-Sébastien Delisle; E Richard Gold
Journal:  Front Med (Lausanne)       Date:  2017-08-16
  10 in total

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