Literature DB >> 20922062

Drug Discovery in Academia- the third way?

Julie Frearson1, Paul Wyatt.   

Abstract

As the pharmaceutical industry continues to re-strategise and focus on low-risk, relatively short term gains for the sake of survival, we need to re-invigorate the early stages of drug discovery and rebalance efforts towards novel modes of action therapeutics and neglected genetic and tropical diseases. Academic drug discovery is one model which offers the promise of new approaches and an alternative organisational culture for drug discovery as it attempts to apply academic innovation and thought processes to the challenge of discovering drugs to address real unmet need.

Entities:  

Year:  2010        PMID: 20922062      PMCID: PMC2948567          DOI: 10.1517/17460441.2010.506508

Source DB:  PubMed          Journal:  Expert Opin Drug Discov        ISSN: 1746-0441            Impact factor:   6.098


  22 in total

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Review 2.  The Critical Path Institute's approach to precompetitive sharing and advancing regulatory science.

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3.  Why academic drug discovery makes sense.

Authors:  Alan P Kozikowski; Bryan Roth; Alexander Tropsha
Journal:  Science       Date:  2006-09-01       Impact factor: 47.728

4.  Drug discovery in jeopardy.

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Journal:  J Clin Invest       Date:  2006-11       Impact factor: 14.808

5.  Drug discovery through industry-academic partnerships.

Authors:  Nathanael S Gray
Journal:  Nat Chem Biol       Date:  2006-12       Impact factor: 15.040

6.  2007 FDA drug approvals: a year of flux.

Authors:  Bethan Hughes
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

Review 7.  Highlights in the discovery of antiviral drugs: a personal retrospective.

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Authors:  Francisco-Javier Gamo; Laura M Sanz; Jaume Vidal; Cristina de Cozar; Emilio Alvarez; Jose-Luis Lavandera; Dana E Vanderwall; Darren V S Green; Vinod Kumar; Samiul Hasan; James R Brown; Catherine E Peishoff; Lon R Cardon; Jose F Garcia-Bustos
Journal:  Nature       Date:  2010-05-20       Impact factor: 49.962

9.  N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Authors:  Julie A Frearson; Stephen Brand; Stuart P McElroy; Laura A T Cleghorn; Ondrej Smid; Laste Stojanovski; Helen P Price; M Lucia S Guther; Leah S Torrie; David A Robinson; Irene Hallyburton; Chidochangu P Mpamhanga; James A Brannigan; Anthony J Wilkinson; Michael Hodgkinson; Raymond Hui; Wei Qiu; Olawale G Raimi; Daan M F van Aalten; Ruth Brenk; Ian H Gilbert; Kevin D Read; Alan H Fairlamb; Michael A J Ferguson; Deborah F Smith; Paul G Wyatt
Journal:  Nature       Date:  2010-04-01       Impact factor: 49.962

10.  Virus-free induction of pluripotency and subsequent excision of reprogramming factors.

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Journal:  Nature       Date:  2009-03-01       Impact factor: 49.962

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  8 in total

1.  Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes.

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2.  Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.

Authors:  L Xiao; M Ding; A Fernandez; P Zhao; L Jin; X Li
Journal:  Eur Cell Mater       Date:  2017-05-09       Impact factor: 3.942

3.  A high content screening approach to identify molecules neuroprotective for photoreceptor cells.

Authors:  John A Fuller; Gillian C Shaw; Delphine Bonnet-Wersinger; Baranda S Hansen; Cynthia A Berlinicke; James Inglese; Donald J Zack
Journal:  Adv Exp Med Biol       Date:  2014       Impact factor: 2.622

Review 4.  Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.

Authors:  Julian Blagg; Paul Workman
Journal:  Cancer Cell       Date:  2017-07-10       Impact factor: 31.743

Review 5.  Natural Products as Modulators of Sirtuins.

Authors:  Berin Karaman Mayack; Wolfgang Sippl; Fidele Ntie-Kang
Journal:  Molecules       Date:  2020-07-20       Impact factor: 4.411

6.  Translational medicines "Ecosystem".

Authors:  Vijay Mahant
Journal:  J Transl Med       Date:  2020-04-06       Impact factor: 5.531

7.  Optimization of Cavity-Based Negative Images to Boost Docking Enrichment in Virtual Screening.

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Review 8.  Improving target assessment in biomedical research: the GOT-IT recommendations.

Authors:  Christoph H Emmerich; Lorena Martinez Gamboa; Martine C J Hofmann; Marc Bonin-Andresen; Olga Arbach; Pascal Schendel; Björn Gerlach; Katja Hempel; Anton Bespalov; Ulrich Dirnagl; Michael J Parnham
Journal:  Nat Rev Drug Discov       Date:  2020-11-16       Impact factor: 112.288

  8 in total

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