Literature DB >> 20404118

Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.

Benoit Witkowski1, Marie-Laure Nicolau, Patrice Njomnang Soh, Xavier Iriart, Sandie Menard, Muriel Alvarez, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, Antoine Berry.   

Abstract

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as possible.

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Year:  2010        PMID： 20404118      PMCID： PMC2897320          DOI： 10.1128/AAC.00209-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon.

Authors:  Anne-Catrin Uhlemann; Michael Ramharter; Bertrand Lell; Peter G Kremsner; Sanjeev Krishna
Journal:  J Infect Dis       Date:  2005-10-07       Impact factor: 5.226

2.  No pfmdr1 amplifications in samples from Guinea-Bissau and Liberia collected between 1981 and 2004.

Authors:  Johan Ursing; Poul-Erik Kofoed; Lars Rombo; J Pedro Gil
Journal:  J Infect Dis       Date:  2006-09-01       Impact factor: 5.226

3.  Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya.

Authors:  Gabrielle Holmgren; Anders Björkman; José Pedro Gil
Journal:  Trop Med Int Health       Date:  2006-12       Impact factor: 2.622

4.  Mefloquine failure in child contracting falciparum malaria in West Africa.

Authors:  F Gay; M H Binet; M D Bustos; B Rouveix; M Danis; C Roy; M Gentilini
Journal:  Lancet       Date:  1990-01-13       Impact factor: 79.321

5.  Reduced in-vitro susceptibility to mefloquine in West African isolates of Plasmodium falciparum.

Authors:  A M Oduola; W K Milhous; L A Salako; O Walker; R E Desjardins
Journal:  Lancet       Date:  1987-12-05       Impact factor: 79.321

6.  Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa.

Authors:  L K Basco; J Le Bras; Z Rhoades; C M Wilson
Journal:  Mol Biochem Parasitol       Date:  1995-11       Impact factor: 1.759

7.  Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria.

Authors:  A Sowunmi; L A Salako
Journal:  Ann Trop Med Parasitol       Date:  1992-02

8.  Monitoring antimalarial resistance: launching a cooperative effort.

Authors:  Carol Hopkins Sibley; Philippe J Guerin; Pascal Ringwald
Journal:  Trends Parasitol       Date:  2010-03-20

9.  Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.

Authors:  Amar Bir Singh Sidhu; Anne-Catrin Uhlemann; Stephanie G Valderramos; Juan-Carlos Valderramos; Sanjeev Krishna; David A Fidock
Journal:  J Infect Dis       Date:  2006-07-11       Impact factor: 5.226

10.  Genomic analysis of mefloquine-resistant Plasmodium falciparum.

Authors:  Khurshida Begum; Hye-Sook Kim; Yohei Okuda; Yusuke Wataya; Mikio Kimura; Takahisa Huruta
Journal:  Nucleic Acids Res Suppl       Date:  2002
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  20 in total

1.  pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies.

Authors:  Benoit Witkowski; Xavier Iriart; Patrice Njomnang Soh; Sandie Menard; Muriel Alvarez; Veronique Naneix-Laroche; Bruno Marchou; Jean-François Magnaval; Françoise Benoit-Vical; Antoine Berry
Journal:  J Clin Microbiol       Date:  2010-07-28       Impact factor: 5.948

2.  Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy.

Authors:  Mónica Guerra; Rita Neres; Patrícia Salgueiro; Cristina Mendes; Nicolas Ndong-Mabale; Pedro Berzosa; Bruno de Sousa; Ana Paula Arez
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

3.  Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum.

Authors:  Matthew S Tucker; Tina Mutka; Kansas Sparks; Janus Patel; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2011-11-14       Impact factor: 5.191

4.  Molecular Surveillance of Plasmodium falciparum Drug Resistance Markers in Clinical Samples from Botswana.

Authors:  Leabaneng Tawe; Michela Menegon; Pleasure Ramatlho; Charles W Muthoga; Naledi Mutukwa; Moses Vurayai; Wame Bothudile; Thato Motshoge; Mariangela L'Episcopia; Tjantilili Mosweunyane; Ishmael Kasvosve; Carlo Severini; Giacomo M Paganotti
Journal:  Am J Trop Med Hyg       Date:  2018-12       Impact factor: 2.345

5.  Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.

Authors:  Nathalie Wurtz; Bécaye Fall; Aurélie Pascual; Silmane Diawara; Kowry Sow; Eric Baret; Bakary Diatta; Khadidiatou B Fall; Pape S Mbaye; Fatou Fall; Yaya Diémé; Christophe Rogier; Raymond Bercion; Sébastien Briolant; Boubacar Wade; Bruno Pradines
Journal:  Malar J       Date:  2012-06-13       Impact factor: 2.979

6.  Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future.

Authors:  Sandie Menard; Isabelle Morlais; Rachida Tahar; Collins Sayang; Pembe Issamou Mayengue; Xavier Iriart; Françoise Benoit-Vical; Brigitte Lemen; Jean-François Magnaval; Parfait Awono-Ambene; Leonardo K Basco; Antoine Berry
Journal:  Malar J       Date:  2012-04-12       Impact factor: 2.979

7.  Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

Authors:  Maria Isabel Veiga; Pedro Eduardo Ferreira; Louise Jörnhagen; Maja Malmberg; Aminatou Kone; Berit Aydin Schmidt; Max Petzold; Anders Björkman; Francois Nosten; Jose Pedro Gil
Journal:  PLoS One       Date:  2011-05-25       Impact factor: 3.240

8.  Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.

Authors:  Marvin Duvalsaint; Melissa D Conrad; Stephen Tukwasibwe; Patrick K Tumwebaze; Jennifer Legac; Roland A Cooper; Philip J Rosenthal
Journal:  Malar J       Date:  2021-06-30       Impact factor: 2.979

Review 9.  Malaria epidemiology and anti-malarial drug efficacy in Guinea: a review of clinical and molecular studies.

Authors:  Mahamoud Sama Cherif; Prabin Dahal; Abdoul Habib Beavogui; Alexandre Delamou; Eugene Kaman Lama; Alioune Camara; Mamadou Pathe Diallo
Journal:  Malar J       Date:  2021-06-16       Impact factor: 2.979

10.  Plasmodium falciparum with multidrug resistance 1 gene duplications, Senegal.

Authors:  Aurélie Pascual; Bécaye Fall; Nathalie Wurtz; Mansour Fall; Cheikhou Camara; Aminata Nakoulima; Eric Baret; Bakary Diatta; Boubacar Wade; Sébastien Briolant; Bruno Pradines
Journal:  Emerg Infect Dis       Date:  2013-05       Impact factor: 6.883
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