Literature DB >> 12903186

Genomic analysis of mefloquine-resistant Plasmodium falciparum.

Khurshida Begum1, Hye-Sook Kim, Yohei Okuda, Yusuke Wataya, Mikio Kimura, Takahisa Huruta.   

Abstract

We studied sequence polymorphism, expression level of pfmdr1 gene and drug sensitivity in mefloquine sensitive-strain as well as mefloquine-resistant clone/24 to understand underlying drug resistance mechanism. Mefloquine-resistant clone/24 exhibited decreased susceptibility to mefloquine, quinine, halofantrine and artemisinin and increased susceptibility to chloroquine. We analyzed sequence of pfmdr1 gene and found mutation in pfmdr1 on clone/24. Moreover, overexpression of mRNA level of pfmdr1 has been observed in mefloquine-resistant clone/24. Our results explain gene mutation and expression level of pfmdr1 may be associated in mefloquine resistance mechanism.

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Year:  2002        PMID： 12903186     DOI： 10.1093/nass/2.1.223

Source DB:  PubMed          Journal:  Nucleic Acids Res Suppl


  3 in total

1.  Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.

Authors:  Benoit Witkowski; Marie-Laure Nicolau; Patrice Njomnang Soh; Xavier Iriart; Sandie Menard; Muriel Alvarez; Bruno Marchou; Jean-François Magnaval; Françoise Benoit-Vical; Antoine Berry
Journal:  Antimicrob Agents Chemother       Date:  2010-04-19       Impact factor: 5.191

2.  Mefloquine exposure induces cell cycle delay and reveals stage-specific expression of the pfmdr1 gene.

Authors:  Elaine B Bohórquez; Jonathan J Juliano; Hyung-Suk Kim; Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

3.  Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future.

Authors:  Sandie Menard; Isabelle Morlais; Rachida Tahar; Collins Sayang; Pembe Issamou Mayengue; Xavier Iriart; Françoise Benoit-Vical; Brigitte Lemen; Jean-François Magnaval; Parfait Awono-Ambene; Leonardo K Basco; Antoine Berry
Journal:  Malar J       Date:  2012-04-12       Impact factor: 2.979
  3 in total

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