Literature DB >> 20401883

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.

Ina C Rosnizeck1, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer.   

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Year:  2010        PMID： 20401883     DOI： 10.1002/anie.200907002

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  41 in total

1.  Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Authors:  Till Maurer; Lindsay S Garrenton; Angela Oh; Keith Pitts; Daniel J Anderson; Nicholas J Skelton; Benjamin P Fauber; Borlan Pan; Shiva Malek; David Stokoe; Mary J C Ludlam; Krista K Bowman; Jiansheng Wu; Anthony M Giannetti; Melissa A Starovasnik; Ira Mellman; Peter K Jackson; Joachim Rudolph; Weiru Wang; Guowei Fang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-19       Impact factor: 11.205

Review 2.  Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Authors:  Shaoyong Lu; Hyunbum Jang; Shuo Gu; Jian Zhang; Ruth Nussinov
Journal:  Chem Soc Rev       Date:  2016-07-11       Impact factor: 54.564

Review 3.  From laptop to benchtop to bedside: structure-based drug design on protein targets.

Authors:  Lu Chen; John K Morrow; Hoang T Tran; Sharangdhar S Phatak; Lei Du-Cuny; Shuxing Zhang
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

4.  Cobalt-based paramagnetic probe to study RNA-protein interactions by NMR.

Authors:  Leah M Seebald; Christopher M DeMott; Srivathsan Ranganathan; Papa Nii Asare-Okai; Anastasia Glazunova; Alan Chen; Alexander Shekhtman; Maksim Royzen
Journal:  J Inorg Biochem       Date:  2017-02-24       Impact factor: 4.155

Review 5.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

6.  High pressure 31P NMR spectroscopy on guanine nucleotides.

Authors:  Michael Spoerner; Matthias Karl; Pedro Lopes; Marcus Hoering; Karoline Loeffel; Andrea Nuehs; Joseph Adelsberger; Werner Kremer; Hans Robert Kalbitzer
Journal:  J Biomol NMR       Date:  2016-12-23       Impact factor: 2.835

Review 7.  The RAS-Effector Interaction as a Drug Target.

Authors:  Adam B Keeton; E Alan Salter; Gary A Piazza
Journal:  Cancer Res       Date:  2017-01-06       Impact factor: 12.701

8.  Pressure dependence of side chain 13C chemical shifts in model peptides Ac-Gly-Gly-Xxx-Ala-NH2.

Authors:  Markus Beck Erlach; Joerg Koehler; Edson Crusca; Claudia E Munte; Masatsune Kainosho; Werner Kremer; Hans Robert Kalbitzer
Journal:  J Biomol NMR       Date:  2017-09-14       Impact factor: 2.835

9.  Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Authors:  Michael C Burns; Qi Sun; R Nathan Daniels; DeMarco Camper; J Phillip Kennedy; Jason Phan; Edward T Olejniczak; Taekyu Lee; Alex G Waterson; Olivia W Rossanese; Stephen W Fesik
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

10.  Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.

Authors:  Priyanka Prakash; Alemayehu A Gorfe
Journal:  Mol Simul       Date:  2014-03-19       Impact factor: 2.178
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