| Literature DB >> 20399149 |
Houtan Noushmehr1, Daniel J Weisenberger, Kristin Diefes, Heidi S Phillips, Kanan Pujara, Benjamin P Berman, Fei Pan, Christopher E Pelloski, Erik P Sulman, Krishna P Bhat, Roel G W Verhaak, Katherine A Hoadley, D Neil Hayes, Charles M Perou, Heather K Schmidt, Li Ding, Richard K Wilson, David Van Den Berg, Hui Shen, Henrik Bengtsson, Pierre Neuvial, Leslie M Cope, Jonathan Buckley, James G Herman, Stephen B Baylin, Peter W Laird, Kenneth Aldape.
Abstract
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds. (c) 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20399149 PMCID： PMC2872684 DOI： 10.1016/j.ccr.2010.03.017
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743