Literature DB >> 21636708

High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression.

Junxia Zhang1, Kai Huang, Zhendong Shi, Jian Zou, Yingyi Wang, Zhifan Jia, Anling Zhang, Lei Han, Xiao Yue, Ning Liu, Tao Jiang, Yongping You, Peiyu Pu, Chunsheng Kang.   

Abstract

Recent data suggest that the β-catenin/Tcf-4 signaling pathway plays an important role in human cancer tumorigenesis. However, the mechanism of β-catenin/Tcf-4 signaling in tumorigenesis is poorly understood. In this study, we show that Tcf-4 protein levels were significantly elevated in high-grade gliomas in comparison with low-grade gliomas and that Tcf-4 levels correlated with levels of AKT2. Reduction of β-catenin/Tcf-4 activity inhibited glioma cell proliferation and invasion in vitro and tumor growth in vivo. This effect of β-catenin/Tcf-4 activity was mediated by AKT2, and in vivo binding of β-catenin/Tcf-4 to the AKT2 promoter was validated using the chromatin immunoprecipitation assay and luciferase reporter assays. Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4.

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Year:  2011        PMID： 21636708      PMCID： PMC3107098          DOI： 10.1093/neuonc/nor034

Source DB:  PubMed          Journal:  Neuro Oncol        ISSN： 1522-8517            Impact factor:   12.300


  29 in total

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Review 2.  Epidemiology and etiology of gliomas.

Authors:  Hiroko Ohgaki; Paul Kleihues
Journal:  Acta Neuropathol       Date:  2005-02-01       Impact factor: 17.088

3.  The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo.

Authors:  Peiyu Pu; Chunsheng Kang; Jie Li; Hao Jiang; Jinquan Cheng
Journal:  J Neurooncol       Date:  2006-01       Impact factor: 4.130

4.  Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion.

Authors:  Peiyu Pu; Chunsheng Kang; Jie Li; Hao Jiang
Journal:  Tumour Biol       Date:  2004 Jul-Aug

5.  Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts.

Authors:  Yongping You; Xiaozeng Geng; Peng Zhao; Zhen Fu; Cunzu Wang; Shengwu Chao; Ning Liu; Ailing Lu; Kevin Gardner; Peiyu Pu; Chunsheng Kong; Yun Ge; Susan I V Judge; Qingdi Q Li
Journal:  Cell Mol Life Sci       Date:  2007-03       Impact factor: 9.261

6.  A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression.

Authors:  Gregory S Yochum; Ryan Cleland; Richard H Goodman
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7.  Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.

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8.  Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.

Authors:  Dexing Fang; David Hawke; Yanhua Zheng; Yan Xia; Jill Meisenhelder; Heinz Nika; Gordon B Mills; Ryuji Kobayashi; Tony Hunter; Zhimin Lu
Journal:  J Biol Chem       Date:  2007-02-07       Impact factor: 5.157

9.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

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Review 10.  MicroRNA roles in beta-catenin pathway.

Authors:  Kai Huang; Jun-Xia Zhang; Lei Han; Yong-Ping You; Tao Jiang; Pei-Yu Pu; Chun-Sheng Kang
Journal:  Mol Cancer       Date:  2010-09-21       Impact factor: 27.401
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  38 in total

Review 1.  Wnt/beta-catenin signaling in glioma.

Authors:  Kailiang Zhang; Junxia Zhang; Lei Han; Peiyu Pu; Chunsheng Kang
Journal:  J Neuroimmune Pharmacol       Date:  2012-03-28       Impact factor: 4.147

2.  VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling.

Authors:  Lingchao Chen; Lei Han; Kailiang Zhang; Zhendong Shi; Junxia Zhang; Anling Zhang; Yongzhi Wang; Yijun Song; Yongli Li; Tao Jiang; Peiyu Pu; Chuanlu Jiang; Chunsheng Kang
Journal:  Neuro Oncol       Date:  2012-05-30       Impact factor: 12.300

3.  AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction.

Authors:  Richard S Beard; Brian A Hoettels; Jamie E Meegan; Travis S Wertz; Byeong J Cha; Xiaoyuan Yang; Julia T Oxford; Mack H Wu; Sarah Y Yuan
Journal:  J Cereb Blood Flow Metab       Date:  2018-12-21       Impact factor: 6.200

4.  The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.

Authors:  M Sarkar; V Khare; K K N Guturi; N Das; M K Ghosh
Journal:  Oncogene       Date:  2015-03-09       Impact factor: 9.867

5.  A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death.

Authors:  Alex Frías; Guillem Lambies; Rosa Viñas-Castells; Catalina Martínez-Guillamon; Natàlia Dave; Antonio García de Herreros; Víctor M Díaz
Journal:  Mol Cell Biol       Date:  2015-12-28       Impact factor: 4.272

6.  Aspirin-/TMZ-coloaded microspheres exert synergistic antiglioma efficacy via inhibition of β-catenin transactivation.

Authors:  Zhen-Dong Shi; Xiao-Min Qian; Chao-Yong Liu; Lei Han; Kai-Liang Zhang; Lu-Yue Chen; Jun-Xia Zhang; Pei-Yu Pu; Xu-Bo Yuan; Chun-Sheng Kang
Journal:  CNS Neurosci Ther       Date:  2012-12-11       Impact factor: 5.243

7.  Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells.

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Journal:  Neuro Oncol       Date:  2012-12-20       Impact factor: 12.300

8.  Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.

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Journal:  EMBO J       Date:  2018-06-14       Impact factor: 11.598

9.  Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution.

Authors:  Pei Yang; Yongzhi Wang; Xiaoxia Peng; Gan You; Wei Zhang; Wei Yan; Zhaoshi Bao; Yinyan Wang; Xiaoguang Qiu; Tao Jiang
Journal:  J Neurooncol       Date:  2013-03-13       Impact factor: 4.130

10.  Molecular interactions of ErbB1 (EGFR) and integrin-β1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance.

Authors:  Miklós Petrás; Tamás Lajtos; Elza Friedländer; Almos Klekner; Eva Pintye; Burt G Feuerstein; János Szöllosi; György Vereb
Journal:  Neuro Oncol       Date:  2013-04-17       Impact factor: 12.300
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