Literature DB >> 20395198

Cbl-b and itch: key regulators of peripheral T-cell tolerance.

K Venuprasad1.   

Abstract

E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-beta (TGF-beta) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer. (c) 2010 AACR.

Entities:  

Keywords:  Foxp3; Tolerance; Tregs; Ubiquitination; tumor Immunity

Mesh：

Substances：

Year:  2010        PMID： 20395198      PMCID： PMC2856114          DOI： 10.1158/0008-5472.CAN-09-4076

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  20 in total

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6.  Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.

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Journal:  J Immunol       Date:  2006-02-01       Impact factor: 5.422

7.  The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.

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Journal:  Nat Immunol       Date:  2008-02-17       Impact factor: 25.606

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Review 3.  Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.

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Review 4.  Ubiquitin makes its mark on immune regulation.

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Review 6.  The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.

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7.  Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood.

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8.  Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation.

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Review 9.  NLRP6 in host defense and intestinal inflammation.

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10.  The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

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