| Literature DB >> 18510923 |
Shimon Sakaguchi1, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono.
Abstract
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.Entities:
Mesh：
Year: 2008 PMID： 18510923 DOI： 10.1016/j.cell.2008.05.009
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582