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Literature DB >> 20388112

Activatable molecular probes for cancer imaging.

Abstract

The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.

Entities: Chemical

Mesh：

Substances：
Molecular Probes

Year: 2010 PMID： 20388112 PMCID： PMC3629980 DOI： 10.2174/156802610791384270

Source DB: PubMed Journal: Curr Top Med Chem ISSN： 1568-0266 Impact factor: 3.295

68 in total

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Journal: Nat Rev Mol Cell Biol Date: 2004-11 Impact factor: 94.444

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Journal: J Med Chem Date: 2005-08-25 Impact factor: 7.446

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Authors: Weibo Cai; Xiaoyuan Chen
Journal: Small Date: 2007-11 Impact factor: 13.281

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Authors: Seulki Lee; Xiaoyuan Chen
Journal: Mol Imaging Date: 2009 Mar-Apr Impact factor: 4.488

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Journal: Bioconjug Chem Date: 1999 Sep-Oct Impact factor: 4.774

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Journal: Curr Opin Struct Biol Date: 2000-12 Impact factor: 6.809

8. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

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Journal: Proc Natl Acad Sci U S A Date: 1996-07-23 Impact factor: 11.205

9. Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.

Authors: Seulki Lee; Ju Hee Ryu; Kyeongsoon Park; Aeju Lee; Seung-Young Lee; In-Chan Youn; Cheol-Hee Ahn; Soon Man Yoon; Seung-Jae Myung; Dae Hyuk Moon; Xiaoyuan Chen; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim
Journal: Nano Lett Date: 2009-12 Impact factor: 11.189

10. Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo.

Authors: Seulki Lee; Kyeongsoon Park; Seung-Young Lee; Ju Hee Ryu; Jong Woong Park; Hyung Jun Ahn; Ick Chan Kwon; In-Chan Youn; Kwangmeyung Kim; Kuiwon Choi
Journal: Bioconjug Chem Date: 2008-08-26 Impact factor: 4.774

26 in total

1. Real-time monitoring of caspase cascade activation in living cells.

Authors: Lei Zhu; Xinglu Huang; Ki Young Choi; Ying Ma; Fan Zhang; Gang Liu; Seulki Lee; Xiaoyuan Chen
Journal: J Control Release Date: 2012-06-01 Impact factor: 9.776

Review 2. Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges.

Authors: Xiaoxiao He; Jinhao Gao; Sanjiv Sam Gambhir; Zhen Cheng
Journal: Trends Mol Med Date: 2010-10-01 Impact factor: 11.951

3. In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity.

Authors: Lei Zhu; Fan Zhang; Ying Ma; Gang Liu; Kwangmeyung Kim; Xuexun Fang; Seulki Lee; Xiaoyuan Chen
Journal: Mol Pharm Date: 2011-11-01 Impact factor: 4.939

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Journal: Chem Soc Rev Date: 2011-05-23 Impact factor: 54.564

Review 5. Deep tissue imaging: a review from a preclinical cancer research perspective.

Authors: Annette Feuchtinger; Axel Walch; Michael Dobosz
Journal: Histochem Cell Biol Date: 2016-10-04 Impact factor: 4.304

6. Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions.

Authors: Lei Zhu; Jin Xie; Magdalena Swierczewska; Fan Zhang; Xin Lin; Xuexun Fang; Gang Niu; Seulki Lee; Xiaoyuan Chen
Journal: Bioconjug Chem Date: 2011-05-24 Impact factor: 4.774

7. Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher.

Authors: Xinglu Huang; Magdalena Swierczewska; Ki Young Choi; Lei Zhu; Ashwinkumar Bhirde; Jinwoo Park; Kwangmeyung Kim; Jin Xie; Gang Niu; Kang Choon Lee; Seulki Lee; Xiaoyuan Chen
Journal: Angew Chem Int Ed Engl Date: 2012-01-02 Impact factor: 15.336