INTRODUCTION: There is growing interest in the safety of oxygen therapy in emergency patients. A Cochrane review of oxygen versus air for patients with acute myocardial infarction (AMI) showed a potentially important, but statistically non-significant, increase in mortality (RR 3.03 (95% CI 0.93 to 9.83)) and concluded a definitive randomised controlled trial (RCT) was needed. OBJECTIVE: To explore the feasibility of conducting an RCT of oxygen versus air in AMI, by exploring the beliefs of UK professionals who treat patients with AMI about oxygen's benefits, and to establish a baseline of reported practice by asking about their use of oxygen. Method A cross-sectional online survey of UK emergency department, cardiology and ambulance staff. RESULT: 524 responses were received. All specialities had over 100 respondents. 98.3% said they always or usually use oxygen. 80% reported having local guidelines that recommended the routine use of oxygen. 55% believed oxygen definitely or probably significantly reduces the risk of death, while only 1.3% reported that they thought 'it may even increase the risk of death.' There were only minor differences across specialities and grades. CONCLUSION: Widespread belief in the benefit of oxygen in AMI may make it difficult to persuade funders of the importance of this issue and health professionals to participate in enrolling patients into a trial in which oxygen would be withheld from half their patients.
INTRODUCTION: There is growing interest in the safety of oxygen therapy in emergency patients. A Cochrane review of oxygen versus air for patients with acute myocardial infarction (AMI) showed a potentially important, but statistically non-significant, increase in mortality (RR 3.03 (95% CI 0.93 to 9.83)) and concluded a definitive randomised controlled trial (RCT) was needed. OBJECTIVE: To explore the feasibility of conducting an RCT of oxygen versus air in AMI, by exploring the beliefs of UK professionals who treat patients with AMI about oxygen's benefits, and to establish a baseline of reported practice by asking about their use of oxygen. Method A cross-sectional online survey of UK emergency department, cardiology and ambulance staff. RESULT: 524 responses were received. All specialities had over 100 respondents. 98.3% said they always or usually use oxygen. 80% reported having local guidelines that recommended the routine use of oxygen. 55% believed oxygen definitely or probably significantly reduces the risk of death, while only 1.3% reported that they thought 'it may even increase the risk of death.' There were only minor differences across specialities and grades. CONCLUSION: Widespread belief in the benefit of oxygen in AMI may make it difficult to persuade funders of the importance of this issue and health professionals to participate in enrolling patients into a trial in which oxygen would be withheld from half their patients.
Authors: Alexander Thomas; Sean van Diepen; Rachel Beekman; Shashank S Sinha; Samuel B Brusca; Carlos L Alviar; Jacob Jentzer; Erin A Bohula; Jason N Katz; Andi Shahu; Christopher Barnett; David A Morrow; Emily J Gilmore; Michael A Solomon; P Elliott Miller Journal: JACC Adv Date: 2022-08-26
Authors: Anjali M Prabhat; M Lakshmi Kuppusamy; Shan K Naidu; Sarath Meduru; Praneeth T Reddy; Abishai Dominic; Mahmood Khan; Brian K Rivera; Periannan Kuppusamy Journal: Front Cardiovasc Med Date: 2018-08-28
Authors: Robin Hofmann; Tamrat Befekadu Abebe; Johan Herlitz; Stefan K James; David Erlinge; Troels Yndigegn; Joakim Alfredsson; Thomas Kellerth; Annica Ravn-Fischer; Sebastian Völz; Jörg Lauermann; Tomas Jernberg; Bertil Lindahl; Sophie Langenskiöld Journal: Front Cardiovasc Med Date: 2021-03-15
Authors: Jens Gottlieb; Philipp Capetian; Uwe Hamsen; Uwe Janssens; Christian Karagiannidis; Stefan Kluge; Marco König; Andreas Markewitz; Monika Nothacker; Sabrina Roiter; Susanne Unverzagt; Wolfgang Veit; Thomas Volk; Christian Witt; René Wildenauer; Heinrich Worth; Thomas Fühner Journal: Med Klin Intensivmed Notfmed Date: 2022-02 Impact factor: 0.840
Authors: B Ronan O'Driscoll; Nawar Diar Bakerly; Ann-Louise Caress; June Roberts; Miriam Gaston; Mark Newton; Janelle Yorke Journal: BMJ Open Respir Res Date: 2016-05-05