Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A splicing-independent function of SF2/ASF in microRNA processing.

Literature DB >> 20385090

A splicing-independent function of SF2/ASF in microRNA processing.

Han Wu¹, Shuying Sun, Kang Tu, Yuan Gao, Bin Xie, Adrian R Krainer, Jun Zhu.

Abstract

Both splicing factors and microRNAs are important regulatory molecules that play key roles in posttranscriptional gene regulation. By miRNA deep sequencing, we identified 40 miRNAs that are differentially expressed upon ectopic overexpression of the splicing factor SF2/ASF. Here we show that SF2/ASF and one of its upregulated microRNAs (miR-7) can form a negative feedback loop: SF2/ASF promotes miR-7 maturation, and mature miR-7 in turn targets the 3'UTR of SF2/ASF to repress its translation. Enhanced microRNA expression is mediated by direct interaction between SF2/ASF and the primary miR-7 transcript to facilitate Drosha cleavage and is independent of SF2/ASF's function in splicing. Other miRNAs, including miR-221 and miR-222, may also be regulated by SF2/ASF through a similar mechanism. These results underscore a function of SF2/ASF in pri-miRNA processing and highlight the potential coordination between splicing control and miRNA-mediated gene repression in gene regulatory networks. 2010 Elsevier Inc. All rights reserved.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20385090 PMCID： PMC3395997 DOI： 10.1016/j.molcel.2010.02.021

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

53 in total

1. A synthetic oscillatory network of transcriptional regulators.

Authors: M B Elowitz; S Leibler
Journal: Nature Date: 2000-01-20 Impact factor: 49.962

2. Initial sequencing and analysis of the human genome.

Authors: E S Lander; L M Linton; B Birren; C Nusbaum; M C Zody; J Baldwin; K Devon; K Dewar; M Doyle; W FitzHugh; R Funke; D Gage; K Harris; A Heaford; J Howland; L Kann; J Lehoczky; R LeVine; P McEwan; K McKernan; J Meldrim; J P Mesirov; C Miranda; W Morris; J Naylor; C Raymond; M Rosetti; R Santos; A Sheridan; C Sougnez; Y Stange-Thomann; N Stojanovic; A Subramanian; D Wyman; J Rogers; J Sulston; R Ainscough; S Beck; D Bentley; J Burton; C Clee; N Carter; A Coulson; R Deadman; P Deloukas; A Dunham; I Dunham; R Durbin; L French; D Grafham; S Gregory; T Hubbard; S Humphray; A Hunt; M Jones; C Lloyd; A McMurray; L Matthews; S Mercer; S Milne; J C Mullikin; A Mungall; R Plumb; M Ross; R Shownkeen; S Sims; R H Waterston; R K Wilson; L W Hillier; J D McPherson; M A Marra; E R Mardis; L A Fulton; A T Chinwalla; K H Pepin; W R Gish; S L Chissoe; M C Wendl; K D Delehaunty; T L Miner; A Delehaunty; J B Kramer; L L Cook; R S Fulton; D L Johnson; P J Minx; S W Clifton; T Hawkins; E Branscomb; P Predki; P Richardson; S Wenning; T Slezak; N Doggett; J F Cheng; A Olsen; S Lucas; C Elkin; E Uberbacher; M Frazier; R A Gibbs; D M Muzny; S E Scherer; J B Bouck; E J Sodergren; K C Worley; C M Rives; J H Gorrell; M L Metzker; S L Naylor; R S Kucherlapati; D L Nelson; G M Weinstock; Y Sakaki; A Fujiyama; M Hattori; T Yada; A Toyoda; T Itoh; C Kawagoe; H Watanabe; Y Totoki; T Taylor; J Weissenbach; R Heilig; W Saurin; F Artiguenave; P Brottier; T Bruls; E Pelletier; C Robert; P Wincker; D R Smith; L Doucette-Stamm; M Rubenfield; K Weinstock; H M Lee; J Dubois; A Rosenthal; M Platzer; G Nyakatura; S Taudien; A Rump; H Yang; J Yu; J Wang; G Huang; J Gu; L Hood; L Rowen; A Madan; S Qin; R W Davis; N A Federspiel; A P Abola; M J Proctor; R M Myers; J Schmutz; M Dickson; J Grimwood; D R Cox; M V Olson; R Kaul; C Raymond; N Shimizu; K Kawasaki; S Minoshima; G A Evans; M Athanasiou; R Schultz; B A Roe; F Chen; H Pan; J Ramser; H Lehrach; R Reinhardt; W R McCombie; M de la Bastide; N Dedhia; H Blöcker; K Hornischer; G Nordsiek; R Agarwala; L Aravind; J A Bailey; A Bateman; S Batzoglou; E Birney; P Bork; D G Brown; C B Burge; L Cerutti; H C Chen; D Church; M Clamp; R R Copley; T Doerks; S R Eddy; E E Eichler; T S Furey; J Galagan; J G Gilbert; C Harmon; Y Hayashizaki; D Haussler; H Hermjakob; K Hokamp; W Jang; L S Johnson; T A Jones; S Kasif; A Kaspryzk; S Kennedy; W J Kent; P Kitts; E V Koonin; I Korf; D Kulp; D Lancet; T M Lowe; A McLysaght; T Mikkelsen; J V Moran; N Mulder; V J Pollara; C P Ponting; G Schuler; J Schultz; G Slater; A F Smit; E Stupka; J Szustakowki; D Thierry-Mieg; J Thierry-Mieg; L Wagner; J Wallis; R Wheeler; A Williams; Y I Wolf; K H Wolfe; S P Yang; R F Yeh; F Collins; M S Guyer; J Peterson; A Felsenfeld; K A Wetterstrand; A Patrinos; M J Morgan; P de Jong; J J Catanese; K Osoegawa; H Shizuya; S Choi; Y J Chen; J Szustakowki
Journal: Nature Date: 2001-02-15 Impact factor: 49.962

Review 3. The spliceosome: design principles of a dynamic RNP machine.

Authors: Markus C Wahl; Cindy L Will; Reinhard Lührmann
Journal: Cell Date: 2009-02-20 Impact factor: 41.582

4. A microRNA imparts robustness against environmental fluctuation during development.

Authors: Xin Li; Justin J Cassidy; Catherine A Reinke; Stephen Fischboeck; Richard W Carthew
Journal: Cell Date: 2009-04-17 Impact factor: 41.582

Review 5. MicroRNAs in cancer.

Authors: Yong Sun Lee; Anindya Dutta
Journal: Annu Rev Pathol Date: 2009 Impact factor: 23.472

Review 10. Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants.

Authors: Ian M Silverman; Fan Li; Brian D Gregory
Journal: Plant Sci Date: 2013-02-01 Impact factor: 4.729

A splicing-independent function of SF2/ASF in microRNA processing.

1. A synthetic oscillatory network of transcriptional regulators.

2. Initial sequencing and analysis of the human genome.

Review 3. The spliceosome: design principles of a dynamic RNP machine.

4. A microRNA imparts robustness against environmental fluctuation during development.

Review 5. MicroRNAs in cancer.

6. SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control.

7. The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.

8. Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells.

9. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

10. Primary microRNA transcripts are processed co-transcriptionally.

1. Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing.

Review 2. The widespread regulation of microRNA biogenesis, function and decay.

Review 3. Regulation of senescence by microRNA biogenesis factors.

4. MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia.

Review 5. The RNAissance family: SR proteins as multifaceted regulators of gene expression.

Review 6. Signaling-mediated regulation of MicroRNA processing.

Review 7. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.

Review 8. MicroRNAs and DNA damage response: implications for cancer therapy.

Review 9. MicroRNA biogenesis pathways in cancer.

Review 10. Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants.