CONTEXT AND OBJECTIVE:Genistein aglycone positively affects postmenopausal symptoms. However, questions about its long-term safety on the thyroid gland still remain. DESIGN: The parent study was a randomized, double-blind, placebo-controlled trial involving 389 osteopenic, postmenopausal women for 24 months. A subcohort (138 patients) continued therapy for an additional year. SETTING: Patients received ambulatory care. PATIENTS AND INTERVENTIONS: Participants received 54 mg of genistein aglycone daily (n = 71) or placebo (n = 67), plus calcium and vitamin D(3) at therapeutic doses. Circulating thyroid hormones (TSH, free T(3), free T(4)) and autoantibodies (thyroid peroxidase, thyroglobulin, and thyroid microsomal antigen) were assessed in 40 genistein and 37 placebo subjects who completed 3 yr. Thyroid hormone receptor (THRalpha and THRbeta) and retinoid receptor (RARalpha, RARgamma, and RXRalpha) expression from peripheral blood monocytes was also evaluated at baseline, 12, 24, and 36 months in all 3-yr completers. RESULTS:Genistein administration over 3 yr did not affect serum thyroid hormones or autoantibodies. In addition, there were no differences in THRalpha, THRbeta, RARalpha, RARgamma, or RXRalpha mRNA expression between groups. CONCLUSION: These data suggest that genistein aglycone intake does not significantly increase the risk of clinical or subclinical hypothyroidism at the dose of 54 mg/d.
RCT Entities:
CONTEXT AND OBJECTIVE:Genisteinaglycone positively affects postmenopausal symptoms. However, questions about its long-term safety on the thyroid gland still remain. DESIGN: The parent study was a randomized, double-blind, placebo-controlled trial involving 389 osteopenic, postmenopausal women for 24 months. A subcohort (138 patients) continued therapy for an additional year. SETTING:Patients received ambulatory care. PATIENTS AND INTERVENTIONS:Participants received 54 mg of genisteinaglycone daily (n = 71) or placebo (n = 67), plus calcium and vitamin D(3) at therapeutic doses. Circulating thyroid hormones (TSH, free T(3), free T(4)) and autoantibodies (thyroid peroxidase, thyroglobulin, and thyroid microsomal antigen) were assessed in 40 genistein and 37 placebo subjects who completed 3 yr. Thyroid hormone receptor (THRalpha and THRbeta) and retinoid receptor (RARalpha, RARgamma, and RXRalpha) expression from peripheral blood monocytes was also evaluated at baseline, 12, 24, and 36 months in all 3-yr completers. RESULTS:Genistein administration over 3 yr did not affect serum thyroid hormones or autoantibodies. In addition, there were no differences in THRalpha, THRbeta, RARalpha, RARgamma, or RXRalpha mRNA expression between groups. CONCLUSION: These data suggest that genisteinaglycone intake does not significantly increase the risk of clinical or subclinical hypothyroidism at the dose of 54 mg/d.
Authors: S Hüser; S Guth; H G Joost; S T Soukup; J Köhrle; L Kreienbrock; P Diel; D W Lachenmeier; G Eisenbrand; G Vollmer; U Nöthlings; D Marko; A Mally; T Grune; L Lehmann; P Steinberg; S E Kulling Journal: Arch Toxicol Date: 2018-08-21 Impact factor: 5.153
Authors: Francene M Steinberg; Michael J Murray; Richard D Lewis; Margaret A Cramer; Paula Amato; Ronald L Young; Stephen Barnes; Karen L Konzelmann; Joan G Fischer; Kenneth J Ellis; Roman J Shypailo; J Kennard Fraley; E O'Brian Smith; William W Wong Journal: Am J Clin Nutr Date: 2010-12-22 Impact factor: 7.045
Authors: D Lee Alekel; Ulrike Genschel; Kenneth J Koehler; Heike Hofmann; Marta D Van Loan; Bonnie S Beer; Laura N Hanson; Charles T Peterson; Mindy S Kurzer Journal: Menopause Date: 2015-02 Impact factor: 2.953
Authors: Serena Tonstad; Karen Jaceldo-Siegl; Mark Messina; Ella Haddad; Gary E Fraser Journal: Public Health Nutr Date: 2015-10-09 Impact factor: 4.022
Authors: Bryant T Conger; Shaoyan Zhang; Daniel Skinner; Stephen B Hicks; Eric J Sorscher; Steven M Rowe; Bradford A Woodworth Journal: JAMA Otolaryngol Head Neck Surg Date: 2013-08-01 Impact factor: 6.223
Authors: Herbert Marini; Francesca Polito; Elena B Adamo; Alessandra Bitto; Francesco Squadrito; Salvatore Benvenga Journal: Front Endocrinol (Lausanne) Date: 2012-07-31 Impact factor: 5.555