Literature DB >> 20356612

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

Guillaume Marti1, Véronique Eparvier, Christian Moretti, Soizic Prado, Philippe Grellier, Nathalie Hue, Odile Thoison, Bernard Delpech, Françoise Guéritte, Marc Litaudon.   

Abstract

In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20356612     DOI： 10.1016/j.phytochem.2010.03.008

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  8 in total

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7.  Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine.

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  8 in total

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