Literature DB >> 20348292

HypC, the anthrone oxidase involved in aflatoxin biosynthesis.

Kenneth C Ehrlich1, Ping Li, Leslie Scharfenstein, Perng-Kuang Chang.   

Abstract

On the basis of gene disruption and enzyme activity, hypC, an open reading frame in the region between the pksA (aflC) and nor-1 (aflD) genes in the aflatoxin biosynthesis gene cluster, encodes a 17-kDa oxidase that converts norsolorinic acid anthrone to norsolorinic acid.

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Year:  2010        PMID： 20348292      PMCID： PMC2869142          DOI： 10.1128/AEM.02495-09

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  11 in total

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3.  Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis.

Authors:  P K Chang; K C Ehrlich; J Yu; D Bhatnagar; T E Cleveland
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4.  Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis.

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5.  Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation.

Authors:  Kenneth C Ehrlich; Perng-Kuang Chang; Jiujiang Yu; Peter J Cotty
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8.  Deconstruction of iterative multidomain polyketide synthase function.

Authors:  Jason M Crawford; Paul M Thomas; Jonathan R Scheerer; Anna L Vagstad; Neil L Kelleher; Craig A Townsend
Journal:  Science       Date:  2008-04-11       Impact factor: 47.728

9.  Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.

Authors:  Jin-Young Chung; Isao Fujii; Shigeharu Harada; Ushio Sankawa; Yutaka Ebizuka
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Review 10.  Potential of Aspergillus flavus genomics for applications in biotechnology.

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Authors:  Scott Griffiths; Carl H Mesarich; Benedetta Saccomanno; Abraham Vaisberg; Pierre J G M De Wit; Russell Cox; Jérôme Collemare
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Review 6.  Subcellular localization of fungal specialized metabolites.

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7.  Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus.

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Review 8.  Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.

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9.  Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products.

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10.  Association with AflR in endosomes reveals new functions for AflJ in aflatoxin biosynthesis.

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