| Literature DB >> 11575949 |
L P Mai1, F Guéritte, V Dumontet, M V Tri, B Hill, O Thoison, D Guénard, T Sévenet.
Abstract
An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one new rhamnosylanthraquinone, 3'-O-acetylfrangulin A (8), several new rhamnosylanthrones, the prinoidin-emodin bianthrones (9A-D), the prinoidin bianthrones (10A,B), and the rhamnepalins (11A-C). A structure-cytotoxic activity relationship study was performed on these isolates and some semisynthetic derivatives.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11575949 DOI： 10.1021/np010030v
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050