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Literature DB >> 20337782

Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity.

Alireza Foroumadi¹, Saeed Emami, Maedeh Sorkhi, Maryam Nakhjiri, Zohreh Nazarian, Samaneh Heydari, Sussan K Ardestani, Fatemeh Poorrajab, Abbas Shafiee.

Abstract

Two types of regioisomeric chromene-based chalcones namely, 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones and 3-(6-methoxy-2H-chromen-3-yl)-1-phenylpropen-1-ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major. The obtained results from in vitro biological assays indicated that chloro-substituted 1-(6-methoxy-2H-chromen-3-yl)-3-phenylpropen-1-ones exhibited excellent activity against Leishmania major at non-cytotoxic concentrations.

Entities: Chemical Species

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Year: 2010 PMID： 20337782 DOI： 10.1111/j.1747-0285.2010.00959.x

Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817

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Cited

8 in total

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Authors: Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal: Chem Rev Date: 2014-11-03 Impact factor: 60.622

2. Activity of synthetic chalcones in hamsters experimentally infected with Leishmania (Viannia) braziliensis.

Authors: Tatiane F P de Mello; Bruna M Cardoso; Sara N Lopes; Heriberto R Bitencourt; Evandra M Voltarelli; Luzmarina Hernandes; Sandra M A Aristides; Maria V C Lonardoni; Thais G V Silveira
Journal: Parasitol Res Date: 2015-06-23 Impact factor: 2.289

3. Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides.

Authors: Adile Ayati; Saeed Emami
Journal: Mol Divers Date: 2013-01-12 Impact factor: 2.943

4. Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Authors: Rawda M Okasha; Fawzia F Alblewi; Tarek H Afifi; Arshi Naqvi; Ahmed M Fouda; Al-Anood M Al-Dies; Ahmed M El-Agrody
Journal: Molecules Date: 2017-03-18 Impact factor: 4.411

5. Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Authors: Hany E A Ahmed; Mohammed A A El-Nassag; Ahmed H Hassan; Rawda M Okasha; Saleh Ihmaid; Ahmed M Fouda; Tarek H Afifi; Ateyatallah Aljuhani; Ahmed M El-Agrody
Journal: J Enzyme Inhib Med Chem Date: 2018-12 Impact factor: 5.051

Chromene-based synthetic chalcones as potent antileishmanial agents: synthesis and biological activity.

Review 1. Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

2. Activity of synthetic chalcones in hamsters experimentally infected with Leishmania (Viannia) braziliensis.

3. Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides.

4. Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

5. Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

6. Synthesis of Polycyclic Ether-Benzopyrans and In Vitro Inhibitory Activity against Leishmania tarentolae.

7. Ultrafast broadband nonlinear optical properties and excited-state dynamics of two bis-chalcone derivatives.

Review 8. Synthesis of Chalcones Derivatives and Their Biological Activities: A Review.