Literature DB >> 20336428

The genetics of pain and analgesia in laboratory animals.

William R Lariviere1, Jeffrey S Mogil.   

Abstract

Pain and analgesia traits are heritable in humans and in mice. To better understand the mechanisms of heritability, animal models that provide greater control than is possible in humans over genotype, previous history, environment, and stimulus parameters are available. This chapter will highlight several common methods to study the genetic mechanisms of heritable sensitivity to pain and pain-related traits in rodents. Methods to demonstrate and estimate the heritability of a trait are discussed, as are genetic correlation analysis and linkage mapping. Practical concerns are highlighted throughout this chapter. Due to limitations on the use of humans for similarly powered experiments, these and other animal models remain an essential component in the study of heritable mechanisms of pain and analgesia.

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Year:  2010        PMID： 20336428      PMCID： PMC2947796          DOI： 10.1007/978-1-60327-323-7_20

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  57 in total

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Journal:  Nat Genet       Date:  2004-11       Impact factor: 38.330

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Journal:  Behav Genet       Date:  1983-07       Impact factor: 2.805

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Authors:  J P Hegmann; B Possidente
Journal:  Behav Genet       Date:  1981-03       Impact factor: 2.805

9.  The heritability of antinociception II: pharmacogenetic mediation of three over-the-counter analgesics in mice.

Authors:  Sonya G Wilson; Camron D Bryant; William R Lariviere; Michael S Olsen; Belinda E Giles; Elissa J Chesler; Jeffrey S Mogil
Journal:  J Pharmacol Exp Ther       Date:  2003-02-20       Impact factor: 4.030

10.  Corticotropin releasing hormone related behavioral and neuroendocrine responses to stress in Lewis and Fischer rats.

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  9 in total

Review 1.  Genetic variability of pain perception and treatment--clinical pharmacological implications.

Authors:  Jörn Lötsch
Journal:  Eur J Clin Pharmacol       Date:  2011-02-23       Impact factor: 2.953

2.  CNS animal fMRI in pain and analgesia.

Authors:  David Borsook; Lino Becerra
Journal:  Neurosci Biobehav Rev       Date:  2010-11-30       Impact factor: 8.989

3.  A Review of Strain and Sex Differences in Response to Pain and Analgesia in Mice.

Authors:  Jennifer C Smith
Journal:  Comp Med       Date:  2019-12-10       Impact factor: 0.982

4.  The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery.

Authors:  Sara Hestehave; Klas S P Abelson; Tina Brønnum Pedersen; Gordon Munro
Journal:  Eur J Pain       Date:  2018-11-09       Impact factor: 3.931

5.  The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury.

Authors:  Sara Hestehave; Klas S P Abelson; Tina Brønnum Pedersen; David P Finn; Daniel R Andersson; Gordon Munro
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.379

6.  Genetic variability affects the response of skeletal muscle to disuse.

Authors:  Camilla Reina Maroni; Michael A Friedman; Yue Zhang; Michael J McClure; Stefania Fulle; Charles R Farber; Henry J Donahue
Journal:  J Musculoskelet Neuronal Interact       Date:  2021-09-01       Impact factor: 2.041

Review 7.  Mouse Anesthesia: The Art and Science.

Authors:  Kaela L Navarro; Monika Huss; Jennifer C Smith; Patrick Sharp; James O Marx; Cholawat Pacharinsak
Journal:  ILAR J       Date:  2021-12-31       Impact factor: 1.521

Review 8.  Nature and nurture of human pain.

Authors:  Inna Belfer
Journal:  Scientifica (Cairo)       Date:  2013-04-02

9.  Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain.

Authors:  Michael A Cooper; Megan M Jack; Janelle M Ryals; Page Hayley; Taylor Escher; Lauren G Koch; Steven L Britton; Shelby M Raupp; Michelle K Winter; Kenneth E McCarson; Paige C Geiger; John P Thyfault; Douglas E Wright
Journal:  Brain Behav       Date:  2017-09-06       Impact factor: 2.708
  9 in total

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