Literature DB >> 20305998

Pre-dementia Alzheimer's trials: overview.

P S Aisen1.   

Abstract

A series of negative clinical trials of disease-modifying agents for Alzheimer's disease has increased pessimism regarding the prospects for important therapeutic advances. But limited efficacy may be attributed in part to the advanced degree of neurodegeneration present at the onset of dementia. To optimize the likelihood of success, it is essential to develop the methodology to allow testing of disease-modifying treatments at an early stage of pathology, when modulation of pathophysiologic mechanisms may yield major clinical benefits.

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Mesh：

Year:  2010        PMID： 20305998     DOI： 10.1007/s12603-010-0065-2

Source DB:  PubMed          Journal:  J Nutr Health Aging        ISSN： 1279-7707            Impact factor:   4.075


  7 in total

1.  Dose ranging for trials through biomarkers of drug effects.

Authors:  W Z Potter
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

2.  Evolving early (pre-dementia) Alzheimer's disease trials: suit the outcomes to the population and study design.

Authors:  R S Doody
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

3.  Study design considerations: conducting global clinical trials in early Alzheimer's disease.

Authors:  R J Schindler
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

4.  The potential and limits for clinical trials for early Alzheimer's disease and some recommendations.

Authors:  L S Schneider
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

5.  Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care.

Authors:  E Richard; S A Ligthart; E P Moll van Charante; W A van Gool
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

6.  Seeing with new eyes: finding a path to early intervention trials in Alzheimer's disease.

Authors:  J M Cedarbaum; G Crans; M Grundman
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

7.  Clinical trials for early (pre-dementia) Alzheimer's disease: a case for mild cognitive impairment.

Authors:  R C Petersen
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075
  7 in total
  10 in total

1.  Pro-dromal sarcopenia.

Authors:  D L Waters
Journal:  J Nutr Health Aging       Date:  2011-12       Impact factor: 4.075

2.  Recruitment, retention and other methodological issues related to clinical trials for Alzheimer's disease.

Authors:  B Vellas
Journal:  J Nutr Health Aging       Date:  2012-04       Impact factor: 4.075

3.  Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative.

Authors:  Joshua D Grill; Lijie Di; Po H Lu; Cathy Lee; John Ringman; Liana G Apostolova; Nicole Chow; Omid Kohannim; Jeffrey L Cummings; Paul M Thompson; David Elashoff
Journal:  Neurobiol Aging       Date:  2012-04-13       Impact factor: 4.673

4.  Choosing Alzheimer's disease prevention clinical trial populations.

Authors:  Joshua D Grill; Sarah E Monsell
Journal:  Neurobiol Aging       Date:  2013-10-09       Impact factor: 4.673

Review 5.  Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.

Authors:  Cédric Annweiler; Olivier Beauchet
Journal:  Drugs Aging       Date:  2012-02-01       Impact factor: 3.923

6.  Early Alzheimer's trials: new developments.

Authors:  B Vellas; P S Aisen
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

7.  Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old.

Authors:  John L Robinson; Laura Molina-Porcel; Maria M Corrada; Kevin Raible; Edward B Lee; Virginia M-Y Lee; Claudia H Kawas; John Q Trojanowski
Journal:  Brain       Date:  2014-07-09       Impact factor: 13.501

Review 8.  Assessing dementia in resource-poor regions.

Authors:  Gladys E Maestre
Journal:  Curr Neurol Neurosci Rep       Date:  2012-10       Impact factor: 5.081

9.  Vitamin D supplements: a novel therapeutic approach for Alzheimer patients.

Authors:  Cedric Annweiler; Spyridon N Karras; Panagiotis Anagnostis; Olivier Beauchet
Journal:  Front Pharmacol       Date:  2014-01-28       Impact factor: 5.810

Review 10.  Prevalence of dementia in Colombian populations.

Authors:  Efraín Amaya Vargas; Ángela Magnolia Ríos Gallardo; Guillermo González Manrrique; Lina M Murcia-Paredes; María Consuelo Angarita Riaño
Journal:  Dement Neuropsychol       Date:  2014 Oct-Dec
  10 in total

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