Literature DB >> 20306001

Clinical trials for early (pre-dementia) Alzheimer's disease: a case for mild cognitive impairment.

R C Petersen1.   

Abstract

A goal of many clinical trials for Alzheimer's disease is to develop disease-modifying therapies for the pre-dementia period of the Alzheimer's disease process. However, there are no clinical criteria for characterizing subjects in this range. The construct of amnestic mild cognitive impairment has been extensively investigated and may provide useful clinical criteria for this clinical stage. It is proposed that the clinical criteria for mild cognitive impairment be enriched with imaging and other biomarkers to improve the specificity of the outcome, and these criteria might suffice for pre-dementia clinical trials.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20306001     DOI： 10.1007/s12603-010-0068-z

Source DB:  PubMed          Journal:  J Nutr Health Aging        ISSN： 1279-7707            Impact factor:   4.075


  7 in total

1.  Mild cognitive impairment: clinical characterization and outcome.

Authors:  R C Petersen; G E Smith; S C Waring; R J Ivnik; E G Tangalos; E Kokmen
Journal:  Arch Neurol       Date:  1999-03

2.  Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project.

Authors:  Katie Palmer; Hui-Xin Wang; Lars Bäckman; Bengt Winblad; Laura Fratiglioni
Journal:  Am J Psychiatry       Date:  2002-03       Impact factor: 18.112

3.  Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts.

Authors:  Sarah Tomaszewski Farias; Dan Mungas; Bruce R Reed; Danielle Harvey; Charles DeCarli
Journal:  Arch Neurol       Date:  2009-09

4.  Mortality in amnestic mild cognitive impairment: a prospective community study.

Authors:  A L Hunderfund; R O Roberts; T C Slusser; C L Leibson; Y E Geda; R J Ivnik; E G Tangalos; R C Petersen
Journal:  Neurology       Date:  2006-11-28       Impact factor: 9.910

Review 5.  Mild cognitive impairment: ten years later.

Authors:  Ronald C Petersen; Rosebud O Roberts; David S Knopman; Bradley F Boeve; Yonas E Geda; Robert J Ivnik; Glenn E Smith; Clifford R Jack
Journal:  Arch Neurol       Date:  2009-12

Review 6.  Mild cognitive impairment as a diagnostic entity.

Authors:  R C Petersen
Journal:  J Intern Med       Date:  2004-09       Impact factor: 8.989

Review 7.  Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria.

Authors:  Bruno Dubois; Howard H Feldman; Claudia Jacova; Steven T Dekosky; Pascale Barberger-Gateau; Jeffrey Cummings; André Delacourte; Douglas Galasko; Serge Gauthier; Gregory Jicha; Kenichi Meguro; John O'brien; Florence Pasquier; Philippe Robert; Martin Rossor; Steven Salloway; Yaakov Stern; Pieter J Visser; Philip Scheltens
Journal:  Lancet Neurol       Date:  2007-08       Impact factor: 44.182
  7 in total
  9 in total

1.  Pro-dromal sarcopenia.

Authors:  D L Waters
Journal:  J Nutr Health Aging       Date:  2011-12       Impact factor: 4.075

2.  Recruitment, retention and other methodological issues related to clinical trials for Alzheimer's disease.

Authors:  B Vellas
Journal:  J Nutr Health Aging       Date:  2012-04       Impact factor: 4.075

Review 3.  Brain fuel metabolism, aging, and Alzheimer's disease.

Authors:  Stephen Cunnane; Scott Nugent; Maggie Roy; Alexandre Courchesne-Loyer; Etienne Croteau; Sébastien Tremblay; Alex Castellano; Fabien Pifferi; Christian Bocti; Nancy Paquet; Hadi Begdouri; M'hamed Bentourkia; Eric Turcotte; Michèle Allard; Pascale Barberger-Gateau; Tamas Fulop; Stanley I Rapoport
Journal:  Nutrition       Date:  2010-10-29       Impact factor: 4.008

4.  Editorial: can we improve care for patients with dementia?

Authors:  J E Morley
Journal:  J Nutr Health Aging       Date:  2011-08       Impact factor: 4.075

5.  Early Alzheimer's trials: new developments.

Authors:  B Vellas; P S Aisen
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

Review 6.  Pre-dementia Alzheimer's trials: overview.

Authors:  P S Aisen
Journal:  J Nutr Health Aging       Date:  2010-04       Impact factor: 4.075

7.  Slowing and Loss of Complexity in Alzheimer's EEG: Two Sides of the Same Coin?

Authors:  Justin Dauwels; K Srinivasan; M Ramasubba Reddy; Toshimitsu Musha; François-Benoît Vialatte; Charles Latchoumane; Jaeseung Jeong; Andrzej Cichocki
Journal:  Int J Alzheimers Dis       Date:  2011-04-13

8.  Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence of APOE and TOMM40 on Brain Integrity.

Authors:  Beata Ferencz; Sari Karlsson; Grégoria Kalpouzos
Journal:  Int J Alzheimers Dis       Date:  2012-04-09

9.  Emotional Processing in Healthy Ageing, Mild Cognitive Impairment, and Alzheimer's Disease.

Authors:  José Cárdenas; María J Blanca; Fernando Carvajal; Sandra Rubio; Carmen Pedraza
Journal:  Int J Environ Res Public Health       Date:  2021-03-09       Impact factor: 3.390
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.