Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary.

An asymmetric synthesis of two anticancer natural products, candenatenins B and C, is described, leading to a revision of the originally assigned stereochemistry. The synthesis follows a Diels-Alder/retro-Diels Alder strategy using a chiral anthracene auxiliary to access both targets with 90% ee. The inherent structural qualities of the auxiliary allow for both regio- and diastereoselective transformations.