Literature DB >> 18554253

Natural compounds: leads or ideas? Bioinspired molecules for drug discovery.

Terence Beghyn1, Rebecca Deprez-Poulain, Nicolas Willand, Benoit Folleas, Benoit Deprez.   

Abstract

In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.

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Year:  2008        PMID： 18554253     DOI： 10.1111/j.1747-0285.2008.00673.x

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  15 in total

1.  Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

Authors:  Hong-Fang Ji; Xue-Juan Li; Hong-Yu Zhang
Journal:  EMBO Rep       Date:  2009-02-20       Impact factor: 8.807

2.  Opportunities in metabolic engineering to facilitate scalable alkaloid production.

Authors:  Effendi Leonard; Weerawat Runguphan; Sarah O'Connor; Kristala Jones Prather
Journal:  Nat Chem Biol       Date:  2009-05       Impact factor: 15.040

3.  Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.

Authors:  Feng Zhu; Chu Qin; Lin Tao; Xin Liu; Zhe Shi; Xiaohua Ma; Jia Jia; Ying Tan; Cheng Cui; Jinshun Lin; Chunyan Tan; Yuyang Jiang; Yuzong Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-18       Impact factor: 11.205

4.  Efficient discovery of bioactive scaffolds by activity-directed synthesis.

Authors:  George Karageorgis; Stuart Warriner; Adam Nelson
Journal:  Nat Chem       Date:  2014-08-24       Impact factor: 24.427

Review 5.  Privileged scaffolds for library design and drug discovery.

Authors:  Matthew E Welsch; Scott A Snyder; Brent R Stockwell
Journal:  Curr Opin Chem Biol       Date:  2010-03-18       Impact factor: 8.822

6.  An extract of Stephania hernandifolia, an ethnomedicinal plant, inhibits herpes simplex virus 1 entry.

Authors:  Joy Mondal; Ananya Das Mahapatra; Keshab C Mandal; Debprasad Chattopadhyay
Journal:  Arch Virol       Date:  2021-05-26       Impact factor: 2.574

7.  A Regioselective Synthesis of Novel Functionalized Organochalcogen Compounds by Chalcogenocyclofunctionalization Reactions Based on Chalcogen Halides and Natural Products.

Authors:  Maxim V Musalov; Vladimir A Potapov; Vladimir A Yakimov; Maria V Musalova; Arkady A Maylyan; Sergey V Zinchenko; Svetlana V Amosova
Journal:  Molecules       Date:  2021-06-18       Impact factor: 4.411

8.  Super Natural II--a database of natural products.

Authors:  Priyanka Banerjee; Jevgeni Erehman; Björn-Oliver Gohlke; Thomas Wilhelm; Robert Preissner; Mathias Dunkel
Journal:  Nucleic Acids Res       Date:  2014-10-09       Impact factor: 16.971

Review 9.  Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives.

Authors:  Amit Pithadia; Jeffrey R Brender; Carol A Fierke; Ayyalusamy Ramamoorthy
Journal:  J Diabetes Res       Date:  2015-11-15       Impact factor: 4.011

10.  Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.

Authors:  Guiomar Pérez-Moreno; Juan Cantizani; Paula Sánchez-Carrasco; Luis Miguel Ruiz-Pérez; Jesús Martín; Noureddine El Aouad; Ignacio Pérez-Victoria; José Rubén Tormo; Víctor González-Menendez; Ignacio González; Nuria de Pedro; Fernando Reyes; Olga Genilloud; Francisca Vicente; Dolores González-Pacanowska
Journal:  PLoS One       Date:  2016-01-06       Impact factor: 3.240
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