Literature DB >> 20303246

Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy.

N G Burnet1, E J Adams, J Fairfoul, G S J Tudor, A C F Hoole, D S Routsis, J C Dean, R D Kirby, M Cowen, S G Russell, Y L Rimmer, S J Thomas.   

Abstract

AIMS: Image-guided radiotherapy (IGRT) and intensity-modulated radiotherapy (IMRT) represent two important technical developments that will probably improve patient outcome. Helical tomotherapy, provided by the TomoTherapy HiArt system, provides an elegant integrated solution providing both technologies, although others are available. Here we report our experience of clinical implementation of daily online IGRT and IMRT using helical tomotherapy.
MATERIALS AND METHODS: Methods were needed to select patients who would probably benefit. Machine-specific commissioning, a quality assurance programme and patient-specific delivery quality assurance were also needed. The planning target volume dose was prescribed as the median dose, with the added criterion that the 95% isodose should cover 99% of the target volume. Although back-up plans, for delivery on conventional linear accelerators, were initially prepared, this practice was abandoned because they were used very rarely.
RESULTS: In the first 12 months, 114 patients were accepted for treatment, and 3343 fractions delivered. New starts averaged 2.6 per week, with an average of 17.5 fractions treated per day, and the total number capped at 22. This has subsequently been raised to 24. Of the first 100 patients, 96 were treated with radical intent. Five were considered to have been untreatable on our standard equipment. IGRT is radiographer led and all patients were imaged daily, with positional correction made before treatment, using an action level of 1mm. A formal training programme was developed and implemented before installation. The in-room time fell significantly during the year, reflecting increasing experience and a software upgrade. More recently, after a couch upgrade in April 2009, the mean in-room time fell to 18.6 min.
CONCLUSIONS: Successful implementation of tomotherapy was the result of careful planning and effective teamwork. Treatment, including daily image guidance, positional correction and intensity-modulated delivery, is fast and efficient, and can be integrated into routine service. This should encourage the adoption of these technologies. Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20303246     DOI: 10.1016/j.clon.2010.02.003

Source DB:  PubMed          Journal:  Clin Oncol (R Coll Radiol)        ISSN: 0936-6555            Impact factor:   4.126


  22 in total

1.  Consideration of the likely benefit from implementation of prostate image-guided radiotherapy using current margin sizes: a radiobiological analysis.

Authors:  G S J Tudor; Y L Rimmer; T B Nguyen; M A Cowen; S J Thomas
Journal:  Br J Radiol       Date:  2012-02-14       Impact factor: 3.039

2.  Prostate positioning using cone-beam computer tomography based on manual soft-tissue registration: interobserver agreement between radiation oncologists and therapists.

Authors:  B A Jereczek-Fossa; C Pobbiati; L Santoro; C Fodor; P Fanti; S Vigorito; G Baroni; D Zerini; O De Cobelli; R Orecchia
Journal:  Strahlenther Onkol       Date:  2013-08-17       Impact factor: 3.621

Review 3.  Treatment planning optimisation in proton therapy.

Authors:  S E McGowan; N G Burnet; A J Lomax
Journal:  Br J Radiol       Date:  2013-01       Impact factor: 3.039

4.  Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.

Authors:  Neil G Burnet; Jessica E Scaife; Marina Romanchikova; Simon J Thomas; Amy M Bates; Emma Wong; David J Noble; Leila Ea Shelley; Simon J Bond; Julia R Forman; Andrew Cf Hoole; Gillian C Barnett; Frederic M Brochu; Michael Pd Simmons; Raj Jena; Karl Harrison; Ping Lin Yeap; Amelia Drew; Emma Silvester; Patrick Elwood; Hannah Pullen; Andrew Sultana; Shannon Yk Seah; Megan Z Wilson; Simon G Russell; Richard J Benson; Yvonne L Rimmer; Sarah J Jefferies; Nicolette Taku; Mark Gurnell; Andrew S Powlson; Carola-Bibiane Schönlieb; Xiaohao Cai; Michael Pf Sutcliffe; Michael A Parker
Journal:  CERN Ideasq J Exp Innov       Date:  2017-06

Review 5.  Proton beam therapy: perspectives on the National Health Service England clinical service and research programme.

Authors:  Neil G Burnet; Ranald I Mackay; Ed Smith; Amy L Chadwick; Gillian A Whitfield; David J Thomson; Matthew Lowe; Norman F Kirkby; Adrian M Crellin; Karen J Kirkby
Journal:  Br J Radiol       Date:  2020-01-14       Impact factor: 3.039

6.  Image-guided radiotherapy of the prostate using daily CBCT: the feasibility and likely benefit of implementing a margin reduction.

Authors:  I F Maund; R J Benson; J Fairfoul; J Cook; R Huddart; A Poynter
Journal:  Br J Radiol       Date:  2014-10-29       Impact factor: 3.039

7.  The value of image-guided intensity-modulated radiotherapy in challenging clinical settings.

Authors:  S J Treece; M Mukesh; Y L Rimmer; S J Tudor; J C Dean; R J Benson; D L Gregory; G Horan; S J Jefferies; S G Russell; M V Williams; C B Wilson; N G Burnet
Journal:  Br J Radiol       Date:  2013-01       Impact factor: 3.039

8.  Image guidance protocols: balancing imaging parameters against scan time.

Authors:  A M Bates; J E Scaife; G S J Tudor; R Jena; M Romanchikova; J C Dean; A C F Hoole; M P D Simmons; N G Burnet
Journal:  Br J Radiol       Date:  2013-10-15       Impact factor: 3.039

9.  Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicity.

Authors:  Latifa Mesbah; Raúl Matute; Sergey Usychkin; Immacolata Marrone; Fernando Puebla; Cristina Mínguez; Rafael García; Graciela García; César Beltrán; Hugo Marsiglia
Journal:  Radiat Oncol       Date:  2011-08-26       Impact factor: 3.481

Review 10.  Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment.

Authors:  J E Scaife; G C Barnett; D J Noble; R Jena; S J Thomas; C M L West; N G Burnet
Journal:  Br J Radiol       Date:  2015-05-26       Impact factor: 3.039

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