Literature DB >> 29177202

Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.

Neil G Burnet1,2, Jessica E Scaife1,2, Marina Romanchikova1,3, Simon J Thomas1,3, Amy M Bates1,4, Emma Wong1,4, David J Noble1,4, Leila Ea Shelley1,5, Simon J Bond1,6, Julia R Forman1,6, Andrew Cf Hoole1,3, Gillian C Barnett1,4, Frederic M Brochu1,7, Michael Pd Simmons1,7, Raj Jena1,2, Karl Harrison1,7, Ping Lin Yeap1,7, Amelia Drew1,7, Emma Silvester1,7, Patrick Elwood1,7, Hannah Pullen1,7, Andrew Sultana1,7, Shannon Yk Seah1,7, Megan Z Wilson1,7, Simon G Russell1,4, Richard J Benson1,4, Yvonne L Rimmer1,4, Sarah J Jefferies1,4, Nicolette Taku1,2, Mark Gurnell1,8, Andrew S Powlson1,8, Carola-Bibiane Schönlieb1,9, Xiaohao Cai1,10, Michael Pf Sutcliffe1,7, Michael A Parker1,7.   

Abstract

The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.

Entities:  

Keywords:  Multidisciplinary; physical sciences; radiation toxicity

Year:  2017        PMID： 29177202      PMCID： PMC5701740          DOI： 10.23726/cij.2017.457

Source DB:  PubMed          Journal:  CERN Ideasq J Exp Innov        ISSN： 2413-9505


  22 in total

1.  Radiotherapy and cancer care in Sweden.

Authors:  Torgil R Möller; Nina Einhorn; Christer Lindholm; Ulrik Ringborg; Hans Svensson
Journal:  Acta Oncol       Date:  2003       Impact factor: 4.089

Review 2.  Geometrical analysis of radiotherapy target volume delineation: a systematic review of reported comparison methods.

Authors:  G G Hanna; A R Hounsell; J M O'Sullivan
Journal:  Clin Oncol (R Coll Radiol)       Date:  2010-09       Impact factor: 4.126

Review 3.  Accurate accumulation of dose for improved understanding of radiation effects in normal tissue.

Authors:  David A Jaffray; Patricia E Lindsay; Kristy K Brock; Joseph O Deasy; W A Tomé
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-03-01       Impact factor: 7.038

Review 4.  History of tomotherapy.

Authors:  T R Mackie
Journal:  Phys Med Biol       Date:  2006-06-20       Impact factor: 3.609

5.  Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy.

Authors:  Weiguo Lu; Gustavo H Olivera; Quan Chen; Kenneth J Ruchala; Jason Haimerl; Sanford L Meeks; Katja M Langen; Patrick A Kupelian
Journal:  Phys Med Biol       Date:  2006-08-15       Impact factor: 3.609

6.  Active contours without edges.

Authors:  T F Chan; L A Vese
Journal:  IEEE Trans Image Process       Date:  2001       Impact factor: 10.856

Review 7.  Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.

Authors:  G C Barnett; S L Kerns; D J Noble; A M Dunning; C M L West; N G Burnet
Journal:  Clin Oncol (R Coll Radiol)       Date:  2015-07-10       Impact factor: 4.126

8.  Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.

Authors:  Jacques Ferlay; Isabelle Soerjomataram; Rajesh Dikshit; Sultan Eser; Colin Mathers; Marise Rebelo; Donald Maxwell Parkin; David Forman; Freddie Bray
Journal:  Int J Cancer       Date:  2014-10-09       Impact factor: 7.396

9.  Accumulated dose to the rectum, measured using dose-volume histograms and dose-surface maps, is different from planned dose in all patients treated with radiotherapy for prostate cancer.

Authors:  Jessica E Scaife; Simon J Thomas; Karl Harrison; Marina Romanchikova; Michael P F Sutcliffe; Julia R Forman; Amy M Bates; Raj Jena; M Andrew Parker; Neil G Burnet
Journal:  Br J Radiol       Date:  2015-07-24       Impact factor: 3.039

10.  Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy.

Authors:  L E A Shelley; J E Scaife; M Romanchikova; K Harrison; J R Forman; A M Bates; D J Noble; R Jena; M A Parker; M P F Sutcliffe; S J Thomas; N G Burnet
Journal:  Radiother Oncol       Date:  2017-04-28       Impact factor: 6.280
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  6 in total

1.  Automated customized retrieval of radiotherapy data for clinical trials, audit and research.

Authors:  Marina Romanchikova; Karl Harrison; Neil G Burnet; Andrew Cf Hoole; Michael Pf Sutcliffe; Michael Andrew Parker; Rajesh Jena; Simon James Thomas
Journal:  Br J Radiol       Date:  2018-01-31       Impact factor: 3.039

2.  Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy.

Authors:  Leila E A Shelley; Michael P F Sutcliffe; Simon J Thomas; David J Noble; Marina Romanchikova; Karl Harrison; Amy M Bates; Neil G Burnet; Raj Jena
Journal:  Phys Imaging Radiat Oncol       Date:  2020-04

3.  Mechanistic modelling supports entwined rather than exclusively competitive DNA double-strand break repair pathway.

Authors:  S P Ingram; J W Warmenhoven; N T Henthorn; E A K Smith; A L Chadwick; N G Burnet; R I Mackay; N F Kirkby; K J Kirkby; M J Merchant
Journal:  Sci Rep       Date:  2019-04-23       Impact factor: 4.379

4.  Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer.

Authors:  Hannah M Laidley; David J Noble; Gill C Barnett; Julia R Forman; Amy M Bates; Richard J Benson; Sarah J Jefferies; Rajesh Jena; Neil G Burnet
Journal:  Radiat Oncol       Date:  2018-05-04       Impact factor: 3.481

5.  Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord.

Authors:  David J Noble; Ping-Lin Yeap; Shannon Y K Seah; Karl Harrison; Leila E A Shelley; Marina Romanchikova; Amy M Bates; Yaolin Zheng; Gillian C Barnett; Richard J Benson; Sarah J Jefferies; Simon J Thomas; Raj Jena; Neil G Burnet
Journal:  Radiother Oncol       Date:  2018-07-23       Impact factor: 6.280

6.  Autosegmentation of the rectum on megavoltage image guidance scans.

Authors:  L E A Shelley; M P F Sutcliffe; K Harrison; J E Scaife; M A Parker; M Romanchikova; S J Thomas; R Jena; N G Burnet
Journal:  Biomed Phys Eng Express       Date:  2019-01-10
  6 in total

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