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Literature DB >> 202735

Electron microscope study of the base sequence homology between simian virus 40 and human papovavirus BK.

Abstract

The base sequence homology between the genomes of simian virus 40 (SV40) and human papovavirus BK (BKV) was studied by the heteroduplex method of Ferguson and Davis (J. Mol. Biol. 94:135-149, 1975). When mounted for microscopy in 30% formamide (Tm-35 degrees C), BKV/SV40 heteroduplexes were an average of 92% double-stranded and contained only two small nonhomologous regions that mapped near the junctions between the early and late regions of the SV40 Genome. At higher formamide concentrations, the fraction of duplex DNA in the BKV/SV40 heteroduplexes decreased, indicating significant base mismatching in the homologous regions. The strongest regions of homology were located in the late region.

Entities: Chemical Species

Mesh：

Substances：
DNA, Viral

Year: 1978 PMID： 202735 PMCID： PMC353916

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

38 in total

1. Malignant transformation of hamster kidney cells by BK virus.

Authors: M Portolani; G Barbanti-Brodano; M L Placa
Journal: J Virol Date: 1975-02 Impact factor: 5.103

2. An electron microscopic method for studying and mapping the region of weak sequence homology between simian virus 40 and polyoma DNAs.

Authors: J Ferguson; R W Davis
Journal: J Mol Biol Date: 1975-05-15 Impact factor: 5.469

Electron microscope study of the base sequence homology between simian virus 40 and human papovavirus BK.

1. Malignant transformation of hamster kidney cells by BK virus.

2. An electron microscopic method for studying and mapping the region of weak sequence homology between simian virus 40 and polyoma DNAs.

3. Excretion of morphological variants of human polyoma virus.

4. A map of temperature-sensitive mutants of simian virus 40.

5. Evidence of chronic persistent infections with polyomaviruses (BK type) in renal transplant recipients.

6. Transplantable hamster tumors induced with the BK virus.

7. Characterization of human papovavirus BK DNA.

8. Sarcoma in a hamster inoculated with BK virus, a human papovavirus.

9. Physical map of the BK virus genome.

10. Common structural antigen of papovaviruses of the simian virus 40-polyoma subgroup.

1. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters.

2. Comparative study of papovavirus DNA: BKV(MM), BKV(WT) and SV40.

3. Transformation of human embryonic kidney cells by human papovarirus BK.

4. Physical mapping of BK virus DNA with SacI, MboII, and AluI restriction endonucleases.

5. Nucleotide sequence of the BK virus DNA segment encoding small t antigen.

6. Common methionine-tryptic peptides near the amino-terminal end of primate papovavirus tumor antigens.

7. BK virus DNA sequence coding for the t and T antigens and evaluation of methods for determining sequence homology.

8. BK virus DNA: cleavage map and sequence analysis.

9. Relationship between the limited and wide host range octopine-type Ti plasmids of Agrobacterium tumefaciens.

10. The association of viruses with urveal melanoma.